N-Nonyldeoxynojirimycin

• 常用名: N-Nonyldeoxynojirimycin
• 英文名: N-Nonyldeoxynojirimycin
• CAS号: 81117-35-3
• 分子量: 289.41
• 密度: 1.112g/cm3
• 沸点: 451.7ºC at 760 mmHg
• 分子式: C₁₅H₃₁NO₄
• 熔点: 101-102ºC
• 闪点: 224.5ºC
• 符号: GHS07
• 信号词: Warning

N-Nonyldeoxynojirimycin用途

N-Nonyldeoxynojirimycin (NN-DNJ) 是一种有效的 alpha-glucosidase 和 alpha-1,6-glucosidase 抑制剂,IC50 值分别为 0.42 和 8.4 μM,可抑制糖原的降解。

N-Nonyldeoxynojirimycin名称

• 中文名: N-Nonyldeoxynojirimycin
• 英文名: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol

N-Nonyldeoxynojirimycin生物活性

• 描述: N-Nonyldeoxynojirimycin (NN-DNJ) 是一种有效的 alpha-glucosidase 和 alpha-1,6-glucosidase 抑制剂,IC50 值分别为 0.42 和 8.4 μM,可抑制糖原的降解。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: 0.42 μM (alpha-glucosidase), 8.4 μM (alpha-1,6-glucosidase)[1]

• 参考文献:

  [1]. Andersson U, et al. Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem Pharmacol. 2004 Feb 15;67(4):697-705.

N-Nonyldeoxynojirimycin物理化学性质

• 密度: 1.112g/cm3
• 沸点: 451.7ºC at 760 mmHg
• 熔点: 101-102ºC
• 分子式: C₁₅H₃₁NO₄
• 分子量: 289.41
• 闪点: 224.5ºC
• 精确质量: 289.22500
• PSA: 84.16000
• LogP: 0.43410
• InChIKey: FTSCEGKYKXESFF-LXTVHRRPSA-N
• SMILES: CCCCCCCCCN1CC(O)C(O)C(O)C1CO
• 折射率: 1.522
• 储存条件: -20°C

N-Nonyldeoxynojirimycin安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H319
• 警示性声明: P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport

N-Nonyldeoxynojirimycin靶点实验

查看更多实验

实验名称：Selectivity index, ratio of CC50 for MDBK cells to EC50 for BVDV NADL infected in MDB... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167913

实验名称：Ratio of IC50 for inhibition of recombinant human GBA using compound incubated at pH ... 来源：ChEMBL 靶标：Lysosomal acid glucosylceramidase External Id：CHEMBL4258352

实验名称：Pharmacological chaperone activity at beta-glucocerebrosidase N370S mutant in Gaucher... 来源：ChEMBL 靶标：Lysosomal acid glucosylceramidase External Id：CHEMBL3788464

实验名称：Cytotoxicity against MDBK cells assessed as cell viability by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL2167914

实验名称：Activation of beta-glucocerebrosidase in human N370S cells assessed as increase of re... 来源：ChEMBL 靶标：Lysosomal acid glucosylceramidase External Id：CHEMBL1687423

实验名称：Antiviral activity against 1 MOI BVDV NADL infected in MDBK cells assessed as reducti... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL2167915

实验名称：Inhibition of Saccharomyces cerevisiae alpha glucosidase 来源：ChEMBL 靶标：Alpha-glucosidase External Id：CHEMBL3788468

实验名称：Inhibition of almond beta glucosidase 来源：ChEMBL 靶标：N/A External Id：CHEMBL3788466

实验名称：Pharmacological chaperone activity at beta-glucocerebrosidase L444P mutant in Gaucher... 来源：ChEMBL 靶标：Lysosomal acid glucosylceramidase External Id：CHEMBL3788465

实验名称：Inhibition of human recombinant imiglucerase using 4-MU-beta-D-Glu as substrate at pH... 来源：ChEMBL 靶标：Lysosomal acid glucosylceramidase External Id：CHEMBL3788472

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N-Nonyldeoxynojirimycin英文别名

• NN-DNJ
• N-Nonyl-deoxynojirimycin
• N-nonyl-1-deoxynojirimycin
• Cromakalim
• N-Nonyl-DNJ
• N-(N-NONYL)DEOXYNOJIRIMYCIN