AC1903

• 常用名: AC1903
• 英文名: AC 1903
• CAS号: 831234-13-0
• 分子量: 303.358
• 密度: 1.2±0.1 g/cm3
• 沸点: 512.4±60.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇N₃O
• 熔点: N/A
• 闪点: 263.7±32.9 °C

AC1903用途

AC1903是一种有效的特异性TRPC5通道抑制剂,IC50为14.7 uM；阻断利鲁唑激活的TRPC5全细胞电流,但即使在高微摩尔浓度下也不能阻断卡巴胆碱(CCh)诱导的TRPC4和OAG诱导的TRPC6电流；特异性阻断蛋白尿大鼠肾小球TRPC5通道活性,在FSGS的转基因大鼠模型中抑制严重蛋白尿并防止足细胞损失。

AC1903名称

• 英文名: 1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine

AC1903生物活性

• 描述: AC1903是一种有效的特异性TRPC5通道抑制剂,IC50为14.7 uM；阻断利鲁唑激活的TRPC5全细胞电流,但即使在高微摩尔浓度下也不能阻断卡巴胆碱(CCh)诱导的TRPC4和OAG诱导的TRPC6电流；特异性阻断蛋白尿大鼠肾小球TRPC5通道活性,在FSGS的转基因大鼠模型中抑制严重蛋白尿并防止足细胞损失。
• 参考文献: References 1. Zhou Y, et al. Science. 2017 Dec 8;358(6368):1332-1336. View Related Products by Target TRP Channel

AC1903物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 512.4±60.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇N₃O
• 分子量: 303.358
• 闪点: 263.7±32.9 °C
• 精确质量: 303.137177
• LogP: 4.23
• InChIKey: OECUWHDVQIITIS-UHFFFAOYSA-N
• SMILES: c1ccc(Cn2c(NCc3ccco3)nc3ccccc32)cc1
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.648
• 储存条件: 2-8°C，密封，干燥

AC1903安全信息

• 危害码 (欧洲): Xi

AC1903靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Specificity screen against TRPC6 for compounds that activate transient receptor poten... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_AG_Counter_C6

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Specificity screen against TRPC6 for compounds that inhibit transient receptor potent... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_Inh_Counter_C6

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

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AC1903英文别名

• MFCD06609959
• 1-Benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine