去氧氟尿苷-d2

更新时间：2024-01-31 17:47:28

去氧氟尿苷-d2用途

多昔福瑞定-d2是氘标记的多昔福瑞定[1]。多昔福瑞定是PC9-DPE2细胞的胸苷磷酸化酶激活剂,IC50为0.62μM。

中文名	去氧氟尿苷-d2
英文名	1-[5-(dideuteriomethyl)-3,4-dihydroxyoxolan-2-yl]-5-fluoropyrimidine-2,4-dione
英文别名	更多

描述	多昔福瑞定-d2是氘标记的多昔福瑞定[1]。多昔福瑞定是PC9-DPE2细胞的胸苷磷酸化酶激活剂,IC50为0.62μM。
相关类别	研究领域 >> 癌症信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
体外研究	氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Dipartimento di Chimica, Università degli Studi della Basilicata, Potenza, In vitro toxicity of N3-methyl-5'-deoxy-5-fluorouridine, a novel metabolite of doxifluridine: a bioanalytical investigation. J Pharm Biomed Anal. 1998 May;17(1):11-6. [3]. Baek IH, Lee BY, Kim MS, Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs. Eur J Drug Metab Pharmacokinet. 2013 Apr 7. [4]. Yoshikawa T, Tsuburaya A, Shimada K, A phase II study of doxifluridine and docetaxel combination chemotherapy for advanced or recurrent gastric cancer. Gastric Cancer. 200912(4):212-8.

1-{5-[(5,5-H)Deoxy]-β-D-glycero-pentofuranosyl}-5-fluoro-2,4(1H,3H)-pyrimidinedione

Doxifluridine-d2

2,4(1H,3H)-Pyrimidinedione, 1-[5-(deoxy-5,5-d)-β-D-glycero-pentofuranosyl]-5-fluoro-