N-去甲盐酸西布曲明

更新时间：2024-01-09 17:45:02

N-去甲盐酸西布曲明结构式	常用名	N-去甲盐酸西布曲明	英文名	Desmethyl Sibutramine hydrochloride
	CAS号	84467-94-7	分子量	302.28
	密度	N/A	沸点	N/A
	分子式	C₁₆H₂₅Cl₂N	熔点	N/A
	MSDS	N/A	闪点	N/A

N-去甲盐酸西布曲明用途

去甲基西布曲明盐酸盐是西布曲明的次级代谢产物,是一种口服活性去甲肾上腺素转运体(NET)和5-羟色胺转运体(SERT)抑制剂。去甲基西布曲明盐酸盐可用于肥胖和食欲抑制剂的研究[1][2][3][4]。

中文名	N-去甲盐酸西布曲明
英文名	1-[1-(4-chlorophenyl)cyclobutyl]-N,3-dimethylbutan-1-amine,hydrochloride
英文别名	更多

描述	去甲基西布曲明盐酸盐是西布曲明的次级代谢产物,是一种口服活性去甲肾上腺素转运体(NET)和5-羟色胺转运体(SERT)抑制剂。去甲基西布曲明盐酸盐可用于肥胖和食欲抑制剂的研究[1][2][3][4]。
相关类别	研究领域 >> 代谢疾病研究领域 >> 神经疾病信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白
靶点	NET and SERT[1]
参考文献	[1]. Talbot PS, et, al. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans. Neuropsychopharmacology. 2010 Feb;35(3):741-51. [2]. Luscombe GP, et, al. The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology. 1989 Feb;28(2):129-34. [3]. Wang J, et, al. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):822-30. [4]. Ponnuru VS, et, al. Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study. J Pharm Anal. 2012 Aug;2(4):249-257.

危险品运输编码	NONH for all modes of transport

N-Desmethylsibutramine hydrochloridehydrochloride

Desmethyl Sibutramine,Hydrochloride Salt

Desmethylsibutramine hydrochloride

mono-Desmethylsibutramine hydrochloride