Lck抑制剂

• 常用名: Lck抑制剂
• 英文名: TC-S 7003
• CAS号: 847950-09-8
• 分子量: 530.62300
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₁H₃₀N₈O
• 熔点: N/A
• 闪点: N/A

Lck抑制剂用途

Lck Inhibitor是新型的Lck抑制剂,IC50为7 nM。

Lck抑制剂名称

• 中文名: Lck抑制剂
• 英文名: 6-(2,6-Dimethylphenyl)-2-{[4-(4-methyl-1-piperazinyl)phenyl]amino }pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one

Lck抑制剂生物活性

• 描述: Lck Inhibitor是新型的Lck抑制剂,IC50为7 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> SRC
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Martin, Matthew W.; Newcomb, John; Nunes, Joseph J.; et al. Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity. Journal of Medicinal Chemistry (2008), 51(6), 1637-1648.

  [2]. Liew, Chin Y.; Ma, Xiao H.; Liu, Xianghui; Yap, Chun W. SVM Model for Virtual Screening of Lck Inhibitors. Journal of Chemical Information and Modeling (2009), 49(4), 877-885.

Lck抑制剂物理化学性质

• 分子式: C₃₁H₃₀N₈O
• 分子量: 530.62300
• 精确质量: 530.25400
• PSA: 83.59000
• LogP: 4.76970
• InChIKey: BHJJWVDKNXABFS-UHFFFAOYSA-N
• SMILES: Cc1cccc(C)c1-n1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n2c3ccccc3nc12
• 储存条件: 2-8℃

Lck抑制剂靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

实验名称：Protein Kinase A (PKA-HiBiT) enzymatic inhibition screen - Functional assay 来源：NCGC External Id：adst_SDR_PKA-KGP

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

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Lck抑制剂英文别名

• Lck Inhibitor