2-(2-乙基苯氧基)-N-(2-甲基-4-(吡咯烷-1-基)苯基)乙酰胺

• 常用名: 2-(2-乙基苯氧基)-N-(2-甲基-4-(吡咯烷-1-基)苯基)乙酰胺
• 英文名: 2-(2-Ethylphenoxy)-N-(2-methyl-4-(pyrrolidin-1-yl)phenyl)acetamide
• CAS号: 848249-35-4
• 分子量: 338.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₆N₂O₂
• 熔点: N/A
• 闪点: N/A

用途

JAMM蛋白抑制剂2(化合物180)是一种有效的JAMM蛋白酶抑制剂,凝血酶、Rpn11和MMP2的IC50分别为10μM、46μM和89μM。JAMM蛋白抑制剂2可用于研究抗癌药物[1]

名称

• 中文名: 2-(2-乙基苯氧基)-N-(2-甲基-4-(吡咯烷-1-基)苯基)乙酰胺
• 英文名: JAMM protein inhibitor 2

生物活性

• 描述: JAMM蛋白抑制剂2(化合物180)是一种有效的JAMM蛋白酶抑制剂,凝血酶、Rpn11和MMP2的IC50分别为10μM、46μM和89μM。JAMM蛋白抑制剂2可用于研究抗癌药物[1]
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  :IC50: 10 μM (thrombin), 46 μM (Rpn11), 89 μM (MMP2)[1]

• 参考文献:

  [1]. Han-Jie Zhou, et al. Methods and compositions for jamm protease inhibition. WO2013123071A1 (compound 180)

物理化学性质

• 分子式: C₂₁H₂₆N₂O₂
• 分子量: 338.44
• InChIKey: BWVQJXWDZCDJJJ-UHFFFAOYSA-N
• SMILES: CCc1ccccc1OCC(=O)Nc1ccc(N2CCCC2)cc1C
• 储存条件: 2-8°C， 干燥

靶点实验

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