PSI-697

• 常用名: PSI-697
• 英文名: PSI-697
• CAS号: 851546-61-7
• 分子量: 367.82600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₈ClNO₃
• 熔点: N/A
• 闪点: N/A

PSI-697用途

PSI-697是一个P-selectin抑制剂。

PSI-697名称

• 中文名: PSI-697
• 英文名: 2-[(4-chlorophenyl)methyl]-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid

PSI-697生物活性

• 描述: PSI-697是一个P-selectin抑制剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Myers DD Jr et al. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg. 2006 Sep;44(3):625-32.

  [2]. Bedard PW et al. Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis. J Pharmacol Exp Ther.

  [3]. Myers DD Jr et al. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. Thromb Haemost. 2007 Mar;97(3):400-7.

PSI-697物理化学性质

• 分子式: C₂₁H₁₈ClNO₃
• 分子量: 367.82600
• 精确质量: 367.09800
• PSA: 70.42000
• LogP: 4.76160
• InChIKey: DIEPFYNZGUUVHD-UHFFFAOYSA-N
• SMILES: O=C(O)c1c(O)c(Cc2ccc(Cl)cc2)nc2c3c(ccc12)CCCC3
• 储存条件: 2-8℃

PSI-697靶点实验

查看更多实验

实验名称：Dose normalized AUC in Sprague-Dawley rat measured per mg of plasma at 3 mg/kg, iv an... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1219457

实验名称：Clearance in Sprague-Dawley rat at 3 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1219456

实验名称：Oral bioavailability in Sprague-Dawley rat at 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1219455

实验名称：Inhibition of recombinant PSGL-1 by surface plasmon resonance assay 来源：ChEMBL 靶标：P-selectin glycoprotein ligand 1 External Id：CHEMBL1219454

实验名称：Aqueous solubility of the compound at pH 9 来源：ChEMBL 靶标：N/A External Id：CHEMBL1219452

实验名称：Aqueous solubility of the compound at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL1219451

实验名称：Aqueous solubility of the compound at pH 6.6 来源：ChEMBL 靶标：N/A External Id：CHEMBL1219450

实验名称：Oral bioavailability in C57B6 mouse at 10 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1219593

实验名称：Half life in human liver microsomes 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1219592

实验名称：Half life in C57B6 mouse liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL1219591

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PSI-697英文别名

• 2-(4-Chloro-benzyl)-3-hydroxy-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid
• UNII-LH1XC916ME
• PSI-697