(S)-(4-氟苯基)-{3-[3-(4-氟苯基)-[1,2,4]二唑-5-基]哌啶-1-基}甲酮

• 常用名: (S)-(4-氟苯基)-{3-[3-(4-氟苯基)-[1,2,4]二唑-5-基]哌啶-1-基}甲酮
• 英文名: ADX-47273
• CAS号: 851881-60-2
• 分子量: 369.365
• 密度: 1.3±0.1 g/cm3
• 沸点: 540.8±60.0 °C at 760 mmHg
• 分子式: C₂₀H₁₇F₂N₃O₂
• 熔点: N/A
• 闪点: 280.9±32.9 °C

用途

ADX-47273是mGluR5正变构调节剂(PAM),EC50值为170nM。

名称

• 中文名: (4-氟苯基)[(3S)-3-[3-(4-氟苯基)-1,2,4-噁二唑-5-基]-1-哌啶基]-甲酮
• 英文名: (4-fluorophenyl)-[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methanone
• 中文别名: (4-氟苯基)[(3S)-3-[3-(4-氟苯基)-1,2,4-噁二唑-5-基]-1-哌啶基]-甲酮

生物活性

• 描述: ADX-47273是mGluR5正变构调节剂(PAM),EC50值为170nM。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. de Paulis T, et al. Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J Med Chem. 2006 Jun 1;49(11):3332-44.

  [2]. Liu F, et al. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008 Dec;327(3):827-39.

  [3]. Xu J, et al. Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning. Learn Mem. 2013 Jul 18;20(8):438-45.

物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 540.8±60.0 °C at 760 mmHg
• 分子式: C₂₀H₁₇F₂N₃O₂
• 分子量: 369.365
• 闪点: 280.9±32.9 °C
• 精确质量: 369.128876
• PSA: 59.23000
• LogP: 3.48
• InChIKey: VXQCCZHCFBHTTD-HNNXBMFYSA-N
• SMILES: O=C(c1ccc(F)cc1)N1CCCC(c2nc(-c3ccc(F)cc3)no2)C1
• 外观性状: white solid
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.580
• 储存条件: -20℃

靶点实验

查看更多实验

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英文别名

• UNII-4C4P7L0W63
• (4-Fluorophenyl){(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl}methanone
• cc-252
• ADX-47273
• ADX 47273