Z16078526

• 常用名: Z16078526
• 英文名: Z16078526
• CAS号: 852222-94-7
• 分子量: 371.41
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₇N₃O₄S
• 熔点: N/A
• 闪点: N/A

Z16078526用途

Z16078526在原代小鼠棕色脂肪细胞中诱导内源性Ucp1表达,促进p38 MAPK磷酸化和脂解。Z16078526激活小鼠棕色脂肪细胞中的产热基因表达和线粒体活性(解偶联呼吸)。Z16078526也刺激小鼠产热[1]。

Z16078526名称

• 英文名: Z16078526

Z16078526生物活性

• 描述: Z16078526在原代小鼠棕色脂肪细胞中诱导内源性Ucp1表达,促进p38 MAPK磷酸化和脂解。Z16078526激活小鼠棕色脂肪细胞中的产热基因表达和线粒体活性(解偶联呼吸)。Z16078526也刺激小鼠产热[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
• 参考文献:

  [1]. Vergnes L, et al. Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation. J Biol Chem. 2020 Oct 30;295(44):15054-15069.

Z16078526物理化学性质

• 分子式: C₁₈H₁₇N₃O₄S
• 分子量: 371.41

Z16078526靶点实验

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实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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