SLEC-11

• 常用名: SLEC-11
• 英文名: SLEC-11
• CAS号: 863761-17-5
• 分子量: 296.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₇FN₂O
• 熔点: N/A
• 闪点: N/A

SLEC-11用途

SLEC-11作为一种潜在的合成致命铅用于胃癌的治疗。AL-GDa62显示等基因乳腺上皮细胞MCF10A-WT(野生型)和MCF10A-CDH1-/-[1]的EC50分别为12.2μM和8.2μM。

SLEC-11名称

• 英文名: SLEC-11

SLEC-11生物活性

• 描述: SLEC-11作为一种潜在的合成致命铅用于胃癌的治疗。AL-GDa62显示等基因乳腺上皮细胞MCF10A-WT(野生型)和MCF10A-CDH1-/-[1]的EC50分别为12.2μM和8.2μM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Andreas Luxenburger, et al. Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer. J Med Chem. 2021 Dec 23;64(24):18114-18142.

SLEC-11物理化学性质

• 分子式: C₁₈H₁₇FN₂O
• 分子量: 296.34

SLEC-11靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Specificity screen against TRPC6 for compounds that activate transient receptor poten... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_AG_Counter_C6

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Specificity screen against TRPC6 for compounds that inhibit transient receptor potent... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_Inh_Counter_C6

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Specificity screen against TRPC6 for compounds that allosterically potentiate transie... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_Alo_Counter_C6

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