Takeda103A

• 常用名: Takeda103A
• 英文名: Takeda103A
• CAS号: 865609-72-9
• 分子量: 463.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₃F₂N₇O
• 熔点: N/A
• 闪点: N/A

Takeda103A用途

Takeda103A是GRK2的有效抑制剂。G蛋白偶联受体(GPCR)是许多生理过程的中心。Takeda103A具有研究心力衰竭的潜力【1】。

Takeda103A名称

• 英文名: Takeda103A

Takeda103A生物活性

• 描述: Takeda103A是GRK2的有效抑制剂。G蛋白偶联受体(GPCR)是许多生理过程的中心。Takeda103A具有研究心力衰竭的潜力【1】。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Waldschmidt HV, et al. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem. 2016;59(8):3793-3807.

Takeda103A物理化学性质

• 分子式: C₂₄H₂₃F₂N₇O
• 分子量: 463.48
• InChIKey: VWBSMGFTNCQOMB-UHFFFAOYSA-N
• SMILES: CCCn1c(CNc2cccc(C(=O)NCc3c(F)cccc3F)c2)nnc1-c1ccncn1
• 外观性状: 固体
• 储存条件: 2-8°C， 密封， 干燥

Takeda103A靶点实验

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实验名称：Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulat... 来源：ChEMBL 靶标：Beta-adrenergic receptor kinase 1 External Id：CHEMBL4040378

实验名称：Inhibition of human PKCalpha active using MBP as substrate after 60 mins in presence ... 来源：ChEMBL 靶标：Protein kinase C alpha type External Id：CHEMBL4040376

实验名称：Inhibition of CYP3A4 (unknown origin) at 10 uM 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4040377

实验名称：Inhibition of recombinant human N-terminal GST-tagged ROCK2 catalytic domain (1 to 55... 来源：ChEMBL 靶标：Rho-associated protein kinase 2 External Id：CHEMBL4040374

实验名称：Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus e... 来源：ChEMBL 靶标：Beta-adrenergic receptor kinase 1 External Id：CHEMBL4040375

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Inhibition of GRK5 (unknown origin) using tubulin as substrate by SDS-PAGE method 来源：ChEMBL 靶标：G protein-coupled receptor kinase 5 External Id：CHEMBL3811362

实验名称：Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE method 来源：ChEMBL 靶标：Rhodopsin kinase GRK1 External Id：CHEMBL3811361

实验名称：Inhibition of full length C-terminal hexahistidine tagged GRK2 (unknown origin) S670A... 来源：ChEMBL 靶标：Beta-adrenergic receptor kinase 1 External Id：CHEMBL3811360

实验名称：Inhibition of ROCK1 (unknown origin) at 10 uM by ADP-Glo kinase assay 来源：ChEMBL 靶标：Rho-associated protein kinase 1 External Id：CHEMBL3811364

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