氟环戊烯基胞嘧啶

• 常用名: 氟环戊烯基胞嘧啶
• 英文名: RX-3117
• CAS号: 865838-26-2
• 分子量: 257.218
• 密度: 1.8±0.1 g/cm3
• 沸点: 516.3±60.0 °C at 760 mmHg
• 分子式: C₁₀H₁₂FN₃O₄
• 熔点: N/A
• 闪点: 266.1±32.9 °C

氟环戊烯基胞嘧啶用途

RX-3117(TV-1360; Fluorocyclopentenylcytosine)是新型胞苷类似物,在多种癌细胞株中证明有抗癌活性,包括吉西他滨耐受细胞株。

氟环戊烯基胞嘧啶名称

• 中文名: RX-3117
• 英文名: RX-3117

氟环戊烯基胞嘧啶生物活性

• 描述: RX-3117(TV-1360; Fluorocyclopentenylcytosine)是新型胞苷类似物,在多种癌细胞株中证明有抗癌活性,包括吉西他滨耐受细胞株。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 癌症
• 参考文献:

  [1]. Peters GJ, et al. Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360). Invest New Drugs. 2013 Dec;31(6):1444-57.

  [2]. Yang MY, et al. A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine. Anticancer Res. 2014 Dec;34(12):6951-9.

氟环戊烯基胞嘧啶物理化学性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 516.3±60.0 °C at 760 mmHg
• 分子式: C₁₀H₁₂FN₃O₄
• 分子量: 257.218
• 闪点: 266.1±32.9 °C
• 精确质量: 257.081177
• LogP: -0.72
• InChIKey: QLLGKCJUPWYJON-HLTSFMKQSA-N
• SMILES: Nc1ccn(C2C(F)=C(CO)C(O)C2O)c(=O)n1
• 蒸汽压: 0.0±3.0 mmHg at 25°C
• 折射率: 1.721
• 储存条件: -20°C，密闭，干燥

氟环戊烯基胞嘧啶靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Confirmatory qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS2-PP-HEK293ACE2-f4-mipe-npc

实验名称：VSVG counterscreen qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-VSVG-PP-HEK293ACE2-f4-mipe-npc

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

实验名称：qHTS drug screen for cell cycle checkpoint inhibitors in PARPi-resistant BRCA-mutant ... 来源：NCGC External Id：FGL-PARP_PEO-CTG96h-MIPE5.0-p1

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氟环戊烯基胞嘧啶英文别名

• 0Z4A82I0JO
• MFCD28502078
• 4-Amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-2(1H)-pyrimidinone