AM841

• 常用名: AM841
• 英文名: AM841
• CAS号: 871978-21-1
• 分子量: 445.66
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₉NO₃S
• 熔点: N/A
• 闪点: N/A

AM841用途

AM841是一种高亲和力的亲电配体。AM841与螺旋6中的半胱氨酸共价相互作用,并激活CB1大麻素受体。AM841减少毛喉素(HY-15371)刺激的cAMP积累。AM841还减缓胃肠道运动[1][2]。

AM841名称

• 英文名: AM841

AM841生物活性

• 描述: AM841是一种高亲和力的亲电配体。AM841与螺旋6中的半胱氨酸共价相互作用,并激活CB1大麻素受体。AM841减少毛喉素(HY-15371)刺激的cAMP积累。AM841还减缓胃肠道运动[1][2]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
• 参考文献:

  [1]. Picone RP, et al. (-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. Mol Pharmacol. 2005 Dec;68(6):1623-35.

  [2]. Keenan CM, et al. AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner. Br J Pharmacol. 2015 May;172(9):2406-18.

AM841物理化学性质

• 分子式: C₂₆H₃₉NO₃S
• 分子量: 445.66

AM841靶点实验

查看更多实验

实验名称：Agonist activity at 3xHA tagged human CB1 receptor expressed in CHO-K1 cells assessed... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5039172

实验名称：Displacement of [3H]CP55940 from CB2 (unknown origin) assessed as reduction in maximu... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL5039171

实验名称：Displacement of [3H]CP55940 from rat brain membrane CB1 assessed as reduction in maxi... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5039170

实验名称：Human CB1 receptor (Cannabinoid receptors) 来源：IUPHAR-DB 靶标：CB1 receptor (Cannabinoid receptors) [Homo sapiens] External Id：56_Human

实验名称：Agonist activity at 3xHA tagged human CB2 receptor expressed in CHO-K1 cells assessed... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL5039173

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