(R)-​Linezolid

• 常用名: (R)-​Linezolid
• 英文名: (R)-Linezolid
• CAS号: 872992-20-6
• 分子量: 337.346
• 密度: 1.3±0.1 g/cm3
• 沸点: 585.5±50.0 °C at 760 mmHg
• 分子式: C₁₆H₂₀FN₃O₄
• 熔点: N/A
• 闪点: 307.9±30.1 °C

(R)-​Linezolid用途

(R)-Linezolid 是 Linezolid (PNU-100766) 的杂质。Linezolid 是恶唑烷酮类合成抗生素的第一个成员,通过抑制细菌蛋白质合成的起始而起作用。

(R)-​Linezolid名称

• 英文名: N-[[(5R)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide

(R)-​Linezolid生物活性

• 描述: (R)-Linezolid 是 Linezolid (PNU-100766) 的杂质。Linezolid 是恶唑烷酮类合成抗生素的第一个成员,通过抑制细菌蛋白质合成的起始而起作用。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Bednarek E, et al. NMR and molecular modeling study, as complementary techniques to capillary electrophoresis method to elucidate the separation mechanism of linezolid enantiomers. J Chromatogr A. 2008 Jun 6;1193(1-2):164-71.

  [2]. Clemett D, et al. Linezolid. Drugs. 2000 Apr;59(4):815-27; discussion 828.

(R)-​Linezolid物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 585.5±50.0 °C at 760 mmHg
• 分子式: C₁₆H₂₀FN₃O₄
• 分子量: 337.346
• 闪点: 307.9±30.1 °C
• 精确质量: 337.143799
• PSA: 74.60000
• LogP: 0.30
• InChIKey: TYZROVQLWOKYKF-CYBMUJFWSA-N
• SMILES: CC(=O)NCC1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.554

(R)-​Linezolid安全信息

• 危险品运输编码: NONH for all modes of transport

(R)-​Linezolid靶点实验

查看更多实验

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：S16 Schwann cell PMP22 intronic element firefly luciferase assay 来源：NCGC 靶标：peripheral myelin protein 22 [Rattus norvegicus] External Id：cmt-p4-fluc-fda_regid

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Compound was evaluated for the inhibition of human FECH at 10uM 来源：ChEMBL 靶标：Ferrochelatase, mitochondrial External Id：CHEMBL3987222

实验名称：Compound was evaluated for the inhibition of human HMBS at 100uM 来源：ChEMBL 靶标：Porphobilinogen deaminase External Id：CHEMBL3987223

实验名称：Cytotoxicity against HEK293 cells (CO-ADD:MA_007); CC50 by cell viability assay in DM... 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL4296191

实验名称：Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MI... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL4296188

实验名称：Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL4296187

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(R)-​Linezolid英文别名

• UNII-ISQ9I6J12J
• N-({(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide
• Zivoxid
• N-({(5R)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide
• Linezolid Impurity 1