Nurr1 agonist 4

• 常用名: Nurr1 agonist 4
• 英文名: Nurr1 agonist 4
• CAS号: 87645-58-7
• 分子量: 218.21
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₀O₄
• 熔点: N/A
• 闪点: N/A

Nurr1 agonist 4用途

Nurr1激动剂4(化合物8)是一种EC50为2.1μM[1]的高亲和力Nurr1兴奋剂。

Nurr1 agonist 4名称

• 英文名: 5-(4-methoxyphenyl)furan-3-carboxylic acid

Nurr1 agonist 4生物活性

• 描述: Nurr1激动剂4(化合物8)是一种EC50为2.1μM[1]的高亲和力Nurr1兴奋剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Marco Ballarotto, et al. De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. J Med Chem. 2023 Jun 22;66(12):8170-8177.

Nurr1 agonist 4物理化学性质

• 分子式: C₁₂H₁₀O₄
• 分子量: 218.21
• 精确质量: 218.05800
• PSA: 59.67000
• LogP: 2.65340
• InChIKey: KGKSJJKOSONHJU-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(C(=O)O)co2)cc1

Nurr1 agonist 4靶点实验

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实验名称：Effect on VMAT2 mRNA expression in human T98G cells incubated for 16 hrs by qPCR anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5343635

实验名称：Binding affinity to recombinant N-terminal His6-tagged human Nurr1 LBD (362 to 598 re... 来源：ChEMBL 靶标：Nuclear receptor subfamily 4 group A member 2 External Id：CHEMBL5343633

实验名称：Effect on TH mRNA expression in human T98G cells incubated for 16 hrs by qPCR analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5343634

实验名称：Binding affinity to recombinant N-terminal His6-tagged human Nurr1 LBD (362 to 598 re... 来源：ChEMBL 靶标：Nuclear receptor subfamily 4 group A member 2 External Id：CHEMBL5343631

实验名称：Binding affinity to recombinant N-terminal His6-tagged human Nurr1 LBD (362 to 598 re... 来源：ChEMBL 靶标：Nuclear receptor subfamily 4 group A member 2 External Id：CHEMBL5343632

实验名称：Agonist activity at full length human Nurr1 transfected in HEK293T cells co-transfect... 来源：ChEMBL 靶标：Nuclear receptor subfamily 4 group A member 2 External Id：CHEMBL5343629

实验名称：Agonist activity at full length human Nurr1 transfected in HEK293T cells co-transfect... 来源：ChEMBL 靶标：Nuclear receptor subfamily 4 group A member 2 External Id：CHEMBL5343630

实验名称：Agonist activity at human Nurr1 transfected in HEK293T cells co-transfected with pFR-... 来源：ChEMBL 靶标：Nuclear receptor subfamily 4 group A member 2 External Id：CHEMBL5343625

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Nurr1 agonist 4英文别名

• 3-Furancarboxylic acid,5-(4-methoxyphenyl)
• 2-(p-Anisyl)furan-4-carboxylic acid