3-(1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY)-5-(1-(PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL)PYRIDIN-2-AMINE

• 常用名: 3-(1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY)-5-(1-(PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL)PYRIDIN-2-AMINE
• 英文名: 3-(1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY)-5-(1-(PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL)PYRIDIN-2-AMINE
• CAS号: 877400-66-3
• 分子量: 450.33700
• 密度: 1.475g/cm3
• 沸点: 599.177ºC at 760 mmHg
• 分子式: C₂₁H₂₂Cl₂FN₅O
• 熔点: N/A
• 闪点: 316.171ºC

名称

• 英文名: 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

物理化学性质

• 密度: 1.475g/cm3
• 沸点: 599.177ºC at 760 mmHg
• 分子式: C₂₁H₂₂Cl₂FN₅O
• 分子量: 450.33700
• 闪点: 316.171ºC
• 精确质量: 449.11900
• PSA: 77.99000
• LogP: 5.94770
• InChIKey: KTEIFNKAUNYNJU-UHFFFAOYSA-N
• SMILES: CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl
• 折射率: 1.673

安全信息

• 海关编码: 2933990090

海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靶点实验

查看更多实验

实验名称：Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhi... 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL1826482

实验名称：Drug screen in LFS_MB_P medulloblastoma cells to determine synergistic drug combinati... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_LFS_MB_P

实验名称：Inhibition of recombinant GST-tagged ALK L1196M mutant (1064 to 1427 residues) (unkno... 来源：ChEMBL 靶标：ALK tyrosine kinase receptor External Id：CHEMBL5140257

实验名称：Drug screen in ICB984 medulloblastoma cells to determine synergistic drug combination... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_ICB984_MB

实验名称： Inhibitory Activity Against Anaplastic Lymphoma Kinase (ALK) from US Patent US100534... 来源：BindingDB 靶标：N/A External Id：BindingDB_237_1

实验名称：Inhibition of recombinant GST-tagged wild type ALK (1064 to 1427 residues) (unknown o... 来源：ChEMBL 靶标：ALK tyrosine kinase receptor External Id：CHEMBL5140258

实验名称：Drug screen in HDN33 neuroblastoma cells to determine synergistic drug combinations t... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HDN33

实验名称：Binding affinity to human recombinant c-MET assessed as inhibition of autophosphoryla... 来源：ChEMBL 靶标：Hepatocyte growth factor receptor External Id：CHEMBL1825352

实验名称：Drug screen in HD-MB03 medulloblastoma cells to determine synergistic drug combinatio... 来源：25008 靶标：N/A External Id：DKFZ_drug_screen_chromothripsis_HD-MB03

实验名称：Metabolic stability in human liver microsome assessed as compound remaining after 30 ... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1825353

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英文别名

• (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
• 3-(1-(2,6-dichloro-3-fluoro-phenyl)ethoxy)-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-amine
• Kinome_3145
• Kinome_3144
• Kinome_3143
• BOCCHEM BC-L-Y016
• 2-PYRIDINAMINE,3-[1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY]-5-[1-(4-PIPERIDINYL)-1H-PYRAZOL-4-YL]