EGFR/HER2/CDK9-IN-1

• 常用名: EGFR/HER2/CDK9-IN-1
• 英文名: EGFR/HER2/CDK9-IN-1
• CAS号: 879730-44-6
• 分子量: 451.56
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₁N₃O₃S₂
• 熔点: N/A
• 闪点: N/A

EGFR/HER2/CDK9-IN-1用途

EGFR/HER2/CDK9-IN-1(化合物4)是EGFR/HER2/CDK9的有效抑制剂,IC50s分别为90.17、131.39和67.04 nM。EGFR/HER2/CDK9-IN-1具有显著的抗肿瘤活性[1]。

EGFR/HER2/CDK9-IN-1名称

• 英文名: EGFR/HER2/CDK9-IN-1

EGFR/HER2/CDK9-IN-1生物活性

• 描述: EGFR/HER2/CDK9-IN-1(化合物4)是EGFR/HER2/CDK9的有效抑制剂,IC50s分别为90.17、131.39和67.04 nM。EGFR/HER2/CDK9-IN-1具有显著的抗肿瘤活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
  信号通路 >> 细胞周期/DNA损伤 >> CDK
• 参考文献:

  [1]. El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345.

EGFR/HER2/CDK9-IN-1物理化学性质

• 分子式: C₂₃H₂₁N₃O₃S₂
• 分子量: 451.56

EGFR/HER2/CDK9-IN-1靶点实验

查看更多实验

实验名称：Binding affinity to human CA9 assessed as inhibition constant by stopped-flow CO2 hyd... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL5104286

实验名称：Binding affinity to human CA12 assessed as inhibition constant by stopped-flow CO2 hy... 来源：ChEMBL 靶标：Carbonic anhydrase 12 External Id：CHEMBL5104287

实验名称：Binding affinity to human CA1 assessed as inhibition constant by stopped-flow CO2 hyd... 来源：ChEMBL 靶标：Carbonic anhydrase 1 External Id：CHEMBL5104284

实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：Binding affinity to human CA2 assessed as inhibition constant by stopped-flow CO2 hyd... 来源：ChEMBL 靶标：Carbonic anhydrase 2 External Id：CHEMBL5104285

实验名称：NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell... 来源：DTP/NCI 靶标：N/A External Id：IGROV1_OneDose

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