FUBP1–IN-1

• 常用名: FUBP1–IN-1
• 英文名: FUBP1–IN-1
• CAS号: 883003-62-1
• 分子量: 405.39
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₄F₃N₃O₂S
• 熔点: N/A
• 闪点: N/A

FUBP1–IN-1用途

FUBP1–IN-1 是一种有效的 FUBP1 抑制剂,干扰 FUBP1 与单链目标 DNA 的 FUSE 序列结合,IC50 值为 11.0 μM。

FUBP1–IN-1名称

• 英文名: FUBP1–IN-1

FUBP1–IN-1生物活性

• 描述: FUBP1–IN-1 是一种有效的 FUBP1 抑制剂,干扰 FUBP1 与单链目标 DNA 的 FUSE 序列结合,IC50 值为 11.0 μM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 11.0 μM (FUBP1)[1]

• 参考文献:

  [1]. Hauck S, et al. Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors. Bioorg Med Chem. 2016 Nov 15;24(22):5717-5729.

FUBP1–IN-1物理化学性质

• 分子式: C₁₉H₁₄F₃N₃O₂S
• 分子量: 405.39
• InChIKey: CLFOYJSEPPNFQZ-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(C(F)(F)F)n3nc(-c4cccs4)cc3n2)cc1OC
• 储存条件: -20°C，密闭，干燥

FUBP1–IN-1靶点实验

查看更多实验

实验名称：Decrease in cell expansion in human Hep3B cells at 10 to 20 uM measured after 48 to 7... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4719434

实验名称：Cell cycle arrest in human Hep3B cells assessed as accumulation at sub-G1 phase at 10... 来源：ChEMBL 靶标：Hep 3B2 External Id：CHEMBL4719435

实验名称：Inhibition of FUBP1 in human Hep3B cells assessed as upregulation of BIK mRNA express... 来源：ChEMBL 靶标：Far upstream element-binding protein 1 External Id：CHEMBL4719432

实验名称：Inhibition of FUBP1 in human Hep3B cells assessed as downregulation of CCND2 mRNA exp... 来源：ChEMBL 靶标：Far upstream element-binding protein 1 External Id：CHEMBL4719433

实验名称：Cell cycle arrest in human Hep3B cells assessed as accumulation at sub-G1 phase at 20... 来源：ChEMBL 靶标：Hep 3B2 External Id：CHEMBL4719436

实验名称：Synergistic cell killing effect in human HepG2 cells assessed as combination index at... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4719437

实验名称：Inhibition of human full length FUBP1 expressed in Escherichia coli BL21 DE3 assessed... 来源：ChEMBL 靶标：Far upstream element-binding protein 1 External Id：CHEMBL4719426

实验名称：Inhibition of full length 6xHis-tagged human FUBP1 expressed in HEK293T cells assesse... 来源：ChEMBL 靶标：Far upstream element-binding protein 1 External Id：CHEMBL4719427

实验名称：Decrease in cell expansion in human Huh-7 cells at 10 to 20 uM measured after 24 hrs ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4719424

实验名称：Inhibition of human full length FUBP1 expressed in Escherichia coli BL21 DE3 assessed... 来源：ChEMBL 靶标：Far upstream element-binding protein 1 External Id：CHEMBL4719425

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