Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde trifluoroacetate salt

• 常用名: Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde trifluoroacetate salt
• 英文名: Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde trifluoroacetate salt
• CAS号: 886462-83-5
• 分子量: 2000.421
• 密度: 1.2±0.1 g/cm3
• 沸点: 1925.0±65.0 °C at 760 mmHg
• 分子式: C₉₅H₁₆₂N₂₀O₂₆
• 熔点: N/A
• 闪点: 1118.0±34.3 °C

用途

胱天蛋白酶-8IN-1是一种有效的胱天蛋白酶-8抑制剂[1]。

名称

• 英文名: Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde trifluoroacetate salt

生物活性

• 描述: 胱天蛋白酶-8IN-1是一种有效的胱天蛋白酶-8抑制剂[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 细胞凋亡 >> 胱天蛋白酶
• 靶点实验:

  Caspase-8

• 参考文献:

  [1]. Joshi SG, et al. Nuclear factor kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity. Infect Immun. 2003 Jul;71(7):4127-36.

物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 1925.0±65.0 °C at 760 mmHg
• 分子式: C₉₅H₁₆₂N₂₀O₂₆
• 分子量: 2000.421
• 闪点: 1118.0±34.3 °C
• 精确质量: 1999.196899
• LogP: 7.38
• InChIKey: COGMWHXRSXGJMX-PWAYNZGCSA-N
• SMILES: CCC(C)C(NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(C)NC(=O)C1CCCN1C(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(NC(=O)C(C)NC(=O)C(C)NC(C)=O)C(C)C)C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(C=O)CC(=O)O)C(C)O.O=C(O)C(F)(F)F
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.531

英文别名

• L-Alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-isoleucyl-N-[(2S,3R)-2-{acetyl[(2S)-1-carboxy-3-oxo-2-pr ;opanyl]amino}-3-hydroxybutanoyl]-L-α-glutamine