Z-Pro-prolinal

• 常用名: Z-Pro-prolinal
• 英文名: Z-Pro-prolinal
• CAS号: 88795-32-8
• 分子量: 330.37800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₂N₂O₄
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

Z-Pro-prolinal用途

Z-Pro-prolinal(N-苄氧羰基-L-脯氨酰-L-脯氨酸)是一种特异的口服活性脯氨酰内肽酶(PREP)抑制剂,对猪PREP[1][2][3]的IC50为0.4 nM。

Z-Pro-prolinal名称

• 英文名: N-Benzyloxycarbonylprolylprolinal

Z-Pro-prolinal生物活性

• 描述: Z-Pro-prolinal(N-苄氧羰基-L-脯氨酰-L-脯氨酸)是一种特异的口服活性脯氨酰内肽酶(PREP)抑制剂,对猪PREP[1][2][3]的IC50为0.4 nM。
• 相关类别:
  研究领域 >> 心血管疾病
• 靶点实验:

  IC50: 0.4 nM (porcine PREP)[2] Ki: 3.7 nM (PREP from bovine brain)[1]

• 体内研究: Z-Pro-prolinal(N-苄氧羰基-L-脯氨酰-L-脯醇)(100 mg/kg；口服；一次)增加大鼠中隔加压素含量[3]。动物模型：雄性Wistar大鼠[3]剂量：100 mg/kg给药：口服一次结果：显著增加了间隔精氨酸加压素(AVP)含量。

Z-Pro-prolinal物理化学性质

• 分子式: C₁₈H₂₂N₂O₄
• 分子量: 330.37800
• 精确质量: 330.15800
• PSA: 66.92000
• LogP: 1.85330
• InChIKey: ORZXYSPOAVJYRU-HOTGVXAUSA-N
• SMILES: O=CC1CCCN1C(=O)C1CCCN1C(=O)OCc1ccccc1

Z-Pro-prolinal安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319
• 警示性声明: P305 + P351 + P338
• 危险品运输编码: NONH for all modes of transport

Z-Pro-prolinal靶点实验

查看更多实验

实验名称：Inhibitory activity was evaluated against Post-proline cleaving enzyme from rat corte... 来源：ChEMBL 靶标：Prolyl endopeptidase External Id：CHEMBL769582

实验名称：Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1... 来源：ChEMBL 靶标：Cholinesterase External Id：CHEMBL4334129

实验名称：Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 m... 来源：ChEMBL 靶标：Acetylcholinesterase External Id：CHEMBL4334128

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：Permeability of the compound after 2.45 hrs by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4334136

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Inhibition of GSK3B (unknown origin) at 10 uM relative to control 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL4334135

实验名称：Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate prei... 来源：ChEMBL 靶标：Prolyl endopeptidase External Id：CHEMBL4334133

实验名称：A screen for compounds that inhibit viral RNA polymerase binding and polymerization a... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Chain A, Poliovirus Polymerase With Gtp External Id：HMS750

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Z-Pro-prolinal英文别名

• N-benzyloxycarbonyl-L-prolyl-L-prolinal
• N-benzyloxycarbonyl-S-prolyl-S-prolinal
• Z-pro-prolinal
• Z-Pro-prolinal