LUF6000

• 常用名: LUF6000
• 英文名: LUF6000
• CAS号: 890087-21-5
• 分子量: 411.32700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₀Cl₂N₄
• 熔点: N/A
• 闪点: N/A

LUF6000用途

LUF6000是人A3腺苷受体变构调节剂。

LUF6000名称

• 中文名: LUF6000
• 英文名: 2-cyclohexyl-N-(3,4-dichlorophenyl)-3H-imidazo[4,5-c]quinolin-4-amine

LUF6000生物活性

• 描述: LUF6000是人A3腺苷受体变构调节剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Gao ZG, Verzijl D, Zweemer A et al. Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers. Biochem Pharmacol. 2011 Sep 15;82(6):658-68. doi: 10.1016/j.bcp.2011.06.017.

  [2]. Szentmiklósi AJ, Cseppento A, Harmati G, Nánási PP. Novel trends in the treatment of cardiovascular disorders: site- and event- selective adenosinergic drugs. Curr Med Chem. 2011;18(8):1164-87.

  [3]. Heitman LH, G?bly?s A, Zweemer AM, et al. A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. J Med Chem. 2009 Feb 26;52(4):926-31.

  [4]. Gao ZG, Ye K, G?bly?s A, et al. Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000. BMC Pharmacol. 2008 Dec 12;8:20.

  [5]. G?bly?s A, Gao ZG, Brussee J, et al. Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. J Med Chem. 2006 Jun 1;49(11):3354-61.

LUF6000物理化学性质

• 分子式: C₂₂H₂₀Cl₂N₄
• 分子量: 411.32700
• 精确质量: 410.10700
• PSA: 56.83000
• LogP: 6.63110
• InChIKey: UWJVRSIGHHSDSJ-UHFFFAOYSA-N
• SMILES: Clc1ccc(Nc2nc3ccccc3c3nc(C4CCCCC4)[nH]c23)cc1Cl
• 储存条件: 2-8℃

LUF6000靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Human A3 receptor (Adenosine receptors) 来源：IUPHAR-DB 靶标：A3 receptor (Adenosine receptors) [Homo sapiens] External Id：21_Human

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Positive allosteric modulation of human A3 adenosine receptor transfected in HEK293 c... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5526121

实验名称：Positive allosteric modulation of human A3 adenosine receptor transfected in HEK293 c... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5526120

实验名称：Positive allosteric modulation of human A3 adenosine receptor transfected in HEK293 c... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5526119

实验名称：Positive allosteric modulation of human A3 adenosine receptor transfected in HEK293 c... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5526118

实验名称：Positive allosteric modulation of human A3 adenosine receptor transfected in HEK293 c... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5526117

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LUF6000英文别名

• luf6000||luf 6000
• cs-1158
• luf6000