PF-945863

• 常用名: PF-945863
• 英文名: PF 945863
• CAS号: 893556-85-9
• 分子量: 824.014
• 密度: 1.3±0.1 g/cm3
• 沸点: 924.7±65.0 °C at 760 mmHg
• 分子式: C₄₄H₆₅N₅O₁₀
• 熔点: N/A
• 闪点: 513.0±34.3 °C

PF-945863用途

PF-945863是一种口服活性大环内酯类抗生素,可用于呼吸道耐多药菌株的研究[1][2]。

PF-945863名称

• 英文名: (3aS,4R,7R,9R,10R,11R,13R,15R)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl}-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside

PF-945863生物活性

• 描述: PF-945863是一种口服活性大环内酯类抗生素,可用于呼吸道耐多药菌株的研究[1][2]。
• 相关类别:
  研究领域 >> 感染
• 体外研究: PF-945863是一种口服活性大环内酯类抗生素[2]。
• 参考文献:

  [1]. Zientek M, et al. In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010;38(8):1322-1327.

  [2]. Magee TV, et al. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009;52(23):7446-7457.

PF-945863物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 924.7±65.0 °C at 760 mmHg
• 分子式: C₄₄H₆₅N₅O₁₀
• 分子量: 824.014
• 闪点: 513.0±34.3 °C
• 精确质量: 823.473145
• LogP: 3.14
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.585

PF-945863英文别名

• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-( ;dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R)-
• (3aS,4R,7R,9R,10R,11R,13R,15R)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-{1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl}-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3] ;oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside