Deltazinone 1

• 常用名: Deltazinone 1
• 英文名: Deltazinone 1
• CAS号: 894554-89-3
• 分子量: 457.578
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₁N₅O₂
• 熔点: N/A
• 闪点: N/A

Deltazinone 1用途

Deltazinone 1(Deltazinone1)是一种新型高选择性PDEδ抑制剂,可抑制PDEδ/Ras与Kd的相互作用8±4 nM；对广泛的药理学相关蛋白显示出优异的选择性；抑制细胞内PDEδ-Ras相互作用Kd为58±17 nM,在一组人胰腺癌细胞系中表现出比Deltarasin更少的非特异性细胞毒性,包括KRas突变和致癌KRas依赖性,降低胰腺癌细胞中Ras介导的信号传导。

Deltazinone 1名称

• 英文名: Deltazinone 1

Deltazinone 1生物活性

• 描述: Deltazinone 1(Deltazinone1)是一种新型高选择性PDEδ抑制剂,可抑制PDEδ/Ras与Kd的相互作用8±4 nM；对广泛的药理学相关蛋白显示出优异的选择性；抑制细胞内PDEδ-Ras相互作用Kd为58±17 nM,在一组人胰腺癌细胞系中表现出比Deltarasin更少的非特异性细胞毒性,包括KRas突变和致癌KRas依赖性,降低胰腺癌细胞中Ras介导的信号传导。
• 参考文献: References 1. Papke B, et al. Nat Commun. 2016 Apr 20;7:11360. View Related Products by Target Ras

Deltazinone 1物理化学性质

• 分子式: C₂₇H₃₁N₅O₂
• 分子量: 457.578
• InChIKey: HZNKNJCWLQLQMJ-UHFFFAOYSA-N
• SMILES: Cc1ccc(-n2nc3c(=O)n(CCCC(=O)NCC(C)c4ccccc4)nc(C)c3c2C)cc1

Deltazinone 1靶点实验

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实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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