Deltazinone 1
Modify Date: 2024-01-06 18:03:30
Deltazinone 1 structure
|
Common Name | Deltazinone 1 | ||
|---|---|---|---|---|
| CAS Number | 894554-89-3 | Molecular Weight | 457.578 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H31N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Deltazinone 1Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM; displays excellent selectivity against a broad panel of pharmacologically relevant proteins; inhibits the PDEδ-Ras interaction in in-cell measurement with Kd of 58±17 nM, exhibits less unspecific cytotoxicity than Deltarasin in a set of human pancreatic cancer cell lines, including KRas mutation and oncogenic KRas-dependence, decreases Ras-mediated signalling in pancreatic cancer cells. |
| Name | Deltazinone 1 |
|---|
| Description | Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM; displays excellent selectivity against a broad panel of pharmacologically relevant proteins; inhibits the PDEδ-Ras interaction in in-cell measurement with Kd of 58±17 nM, exhibits less unspecific cytotoxicity than Deltarasin in a set of human pancreatic cancer cell lines, including KRas mutation and oncogenic KRas-dependence, decreases Ras-mediated signalling in pancreatic cancer cells. |
|---|---|
| References | References 1. Papke B, et al. Nat Commun. 2016 Apr 20;7:11360. View Related Products by Target Ras |
| Molecular Formula | C27H31N5O2 |
|---|---|
| Molecular Weight | 457.578 |