BRD7586

• 常用名: BRD7586
• 英文名: BRD7586
• CAS号: 895460-70-5
• 分子量: 407.89436
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₄ClN₃O₃S₂
• 熔点: N/A
• 闪点: N/A

BRD7586用途

BRD7586是SpCas9的细胞渗透性小分子抑制剂。BRD7586是已知最小的抗CRISPR[1]。

BRD7586名称

• 英文名: 3-(4-chlorophenyl)sulfonyl-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)propanamide

BRD7586生物活性

• 描述: BRD7586是SpCas9的细胞渗透性小分子抑制剂。BRD7586是已知最小的抗CRISPR[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 细胞周期/DNA损伤 >> CRISPR/Cas9
• 体外研究: 编号7586在细胞中特异性地与 SpCas9蛋白结合,但不与 Cas12a型结合[1]。 BRD7586(0-20μM；24小时)在 HiBiT敲门试验中,呈剂量依赖性地抑制 SpCas9[1]BRD7586(20μM；48小时)增强 293吨细胞中中靶与脱靶的比值[1]。
• 参考文献:

  [1]. Lim D, et al. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nat Cell Biol. 2022 Dec;24(12):1766-1775.

BRD7586物理化学性质

• 分子式: C₁₇H₁₄ClN₃O₃S₂
• 分子量: 407.89436
• InChIKey: MLSIIIMAQNQEOV-UHFFFAOYSA-N
• SMILES: O=C(CCS(=O)(=O)c1ccc(Cl)cc1)Nc1nc(-c2ccncc2)cs1

BRD7586靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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