Glucagon-Like Peptide (GLP) II, human

• 常用名: Glucagon-Like Peptide (GLP) II, human
• 英文名: Glucagon-Like Peptide (GLP) II, human
• CAS号: 89750-15-2
• 分子量: 3766.2
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆₅H₂₅₄N₄₄O₅₅S
• 熔点: N/A
• 闪点: N/A

Glucagon-Like Peptide (GLP) II, human用途

Glucagon-Like Peptide (GLP) II, human 是由原胰高血糖素 C 端衍生的33 氨基酸肽,主要由肠道L细胞产生。Glucagon-Like Peptide (GLP) II 可刺激肠粘膜生长,减少肠细胞的凋亡。

Glucagon-Like Peptide (GLP) II, human名称

• 中文名: Glucagon-like peptide 2 游离态
• 英文名: (2S)-2-[[(2S,3R)-2-[[(2S,3S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S,3R)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]-3-carboxy-propanoyl]amino]acetyl]amino]-3-hydroxy-propanoyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-propanoyl]amino]-3-carboxy-propanoyl]amino]-4-carboxy-butanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-4-oxo-butanoyl]amino]-3-hydroxy-butanoyl]amino]-3-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-carboxy-propanoyl]amino]-4-oxo-butanoyl]amino]-4-methyl-pentanoyl]amino]propanoyl]amino]propanoyl]amino]-5-guanidino-pentanoyl]amino]-3-carboxy-propanoyl]amino]-3-phenyl-propanoyl]amino]-3-methyl-pentanoyl]amino]-4-oxo-butanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methyl-pentanoyl]amino]-3-methyl-pentanoyl]amino]-5-oxo-pentanoyl]amino]-3-hydroxy-butanoyl]amino]hexanoyl]amino]-3-methyl-pentanoyl]amino]-3-hydroxy-butanoyl]amino]butanedioic acid

Glucagon-Like Peptide (GLP) II, human生物活性

• 描述: Glucagon-Like Peptide (GLP) II, human 是由原胰高血糖素 C 端衍生的33 氨基酸肽,主要由肠道L细胞产生。Glucagon-Like Peptide (GLP) II 可刺激肠粘膜生长,减少肠细胞的凋亡。
• 相关类别:
  研究领域 >> 代谢疾病
• 靶点实验:

  Human Endogenous Metabolite

• 参考文献:

  [1]. Drucker DJ, et al. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7911-6.

Glucagon-Like Peptide (GLP) II, human物理化学性质

• 分子式: C₁₆₅H₂₅₄N₄₄O₅₅S
• 分子量: 3766.2
• InChIKey: TWSALRJGPBVBQU-PKQQPRCHSA-N
• SMILES: CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC(N)=O)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(NC(=O)C(CC(N)=O)NC(=O)C(CCSC)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)CC)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(C(=O)NC(CC(=O)O)C(=O)O)C(C)O)C(C)CC)C(C)O)C(C)CC
• 储存条件: -20°C，避光，惰性气体保存

Glucagon-Like Peptide (GLP) II, human安全信息

• 危害码 (欧洲): Xi

Glucagon-Like Peptide (GLP) II, human靶点实验

查看更多实验

实验名称：Agonist activity at human GLP1R expressed in HEK293 cells after 5 hrs by luciferase r... 来源：ChEMBL 靶标：Glucagon-like peptide 1 receptor External Id：CHEMBL3824477

实验名称：Agonist activity at human GLP2R expressed in HEK293 cells after 5 hrs by luciferase r... 来源：ChEMBL 靶标：Glucagon-like peptide 2 receptor External Id：CHEMBL3824476

实验名称：Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assess... 来源：ChEMBL 靶标：Glucagon-like peptide 2 receptor External Id：CHEMBL2183535

实验名称：Selectivity ratio of EC50 for human GLP1R expressed in HEK293 cells to EC50 for human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3824480

实验名称：Agonist activity at human GLP1R expressed in HEK293 cells at 30 nM after 5 hrs by luc... 来源：ChEMBL 靶标：Glucagon-like peptide 1 receptor External Id：CHEMBL3824479

实验名称：Potency index, ratio of compound EC50 to compound 2 EC50 for human GLP2R expressed in... 来源：ChEMBL 靶标：Glucagon-like peptide 2 receptor External Id：CHEMBL3824478

实验名称：Protein binding in rat plasma at 200 to 1000 ng/ml incubated for 15 mins by LC/MS/MS ... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3824485

实验名称：Systemic clearance in Sprague-Dawley rat at 0.2 mg/kg, iv through cassette dosing mea... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3824482

实验名称：Agonist activity at human GLP1 receptor expressed in HEK293 cells assessed as increas... 来源：ChEMBL 靶标：Glucagon-like peptide 1 receptor External Id：CHEMBL4257414

实验名称：Agonist activity at human GLP2 receptor expressed in HEK293 cells assessed as increas... 来源：ChEMBL 靶标：Glucagon-like peptide 2 receptor External Id：CHEMBL4257413

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