NVP-LCQ195

• 常用名: NVP-LCQ195
• 英文名: NVP-LCQ195
• CAS号: 902156-99-4
• 分子量: 460.33500
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₉Cl₂N₅O₄S
• 熔点: N/A
• 闪点: N/A

NVP-LCQ195用途

NVP-LCQ195 (AT9311; LCQ195)是CDK杂环类抑制剂,对CDK1,CDK2,CDK3和CDK5的IC50为1-42 nM。

NVP-LCQ195名称

• 中文名: NVP-LCQ195
• 英文名: 4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide

NVP-LCQ195生物活性

• 描述: NVP-LCQ195 (AT9311; LCQ195)是CDK杂环类抑制剂,对CDK1,CDK2,CDK3和CDK5的IC50为1-42 nM。
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  Cdk5/p25:1 nM (IC50)

  CDK5/p35:1 nM (IC50)

  Cdk1/cyclin B:2 nM (IC50)

  cdk2/cyclin A:2 nM (IC50)

  CDK2/cyclinE:5 nM (IC50)

  CDK9/cyclinT1:15 nM (IC50)

  CDK3/Cyclin E:42 nM (IC50)

  cdk6/cyclin D3:187 nM (IC50)

  CDK7/Cyclin H/MAT1:3564 nM (IC50)

• 参考文献:

  [1]. McMillin DW, Delmore J, Negri J et al. Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications. Br J Haematol. 2011 Feb;152(4):420-32.

NVP-LCQ195物理化学性质

• 分子式: C₁₇H₁₉Cl₂N₅O₄S
• 分子量: 460.33500
• 精确质量: 459.05300
• PSA: 136.13000
• LogP: 3.91620
• InChIKey: CCUXEBOOTMDSAM-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)N1CCC(NC(=O)c2[nH]ncc2NC(=O)c2c(Cl)cccc2Cl)CC1
• 储存条件: -20°C

NVP-LCQ195靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-H295R-72hr

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Confirmatory qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS2-PP-HEK293ACE2-f4-mipe-npc

实验名称：VSVG counterscreen qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-VSVG-PP-HEK293ACE2-f4-mipe-npc

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

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NVP-LCQ195英文别名

• CS-0840
• AT 9311
• 4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl)amide
• NVP LCQ195
• LCQ 195
• NVP-LCQ195