NSC260594

• 常用名: NSC260594
• 英文名: NSC260594
• CAS号: 906718-66-9
• 分子量: 504.55
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₄N₆O₃
• 熔点: N/A
• 闪点: N/A

NSC260594用途

NSC260594(NSC 260594)是HIV-1 RNA包装的特异性抑制剂,其涉及通过稳定这种小RNA茎环来阻止Gag与SL3的相互作用,然后导致全局包装信号区域(psi或ψ)的稳定化；特异性阻断HIV-1 RNA衣壳化,与HIV-1 gRNA结合并表现出有效的抗病毒作用活性；NSC260594也是大肠杆菌缩合素MukBEF的小分子抑制剂,直接影响MukB。

NSC260594名称

• 英文名: NSC260594

NSC260594生物活性

• 描述: NSC260594(NSC 260594)是HIV-1 RNA包装的特异性抑制剂,其涉及通过稳定这种小RNA茎环来阻止Gag与SL3的相互作用,然后导致全局包装信号区域(psi或ψ)的稳定化；特异性阻断HIV-1 RNA衣壳化,与HIV-1 gRNA结合并表现出有效的抗病毒作用活性；NSC260594也是大肠杆菌缩合素MukBEF的小分子抑制剂,直接影响MukB。
• 参考文献: References 1. Ingemarsdotter CK, et al. Retrovirology. 2018 Mar 14;15(1):25. 2. Zhao H, et al. ACS Infect Dis. 2018 Oct 22. doi: 10.1021/acsinfecdis.8b00222. View Related Products by Target HIV

NSC260594物理化学性质

• 分子式: C₂₉H₂₄N₆O₃
• 分子量: 504.55
• InChIKey: SDVVSJQTYKFAFR-UHFFFAOYSA-N
• SMILES: Cn1ccc(=Nc2ccc(NC(=O)c3ccc(N=c4ccn(C)c5ccc([N+](=O)[O-])cc45)cc3)cc2)cc1

NSC260594靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Single Concentration Validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase U... 来源：Burnham Center for Chemical Genomics 靶标：COP9 signalosome complex subunit 5 [Homo sapiens] External Id：SBCCG-A995-CSN5-CP-Assay

实验名称：Single concentration validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase H... 来源：Burnham Center for Chemical Genomics 靶标：72 kDa type IV collagenase isoform a preproprotein [Homo sapiens] External Id：SBCCG-A996-CSN5-MMP2-CP-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

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