CHK1-IN-2

• 常用名: CHK1-IN-2
• 英文名: CHK1-IN-2
• CAS号: 912367-45-4
• 分子量: 366.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₂N₄OS
• 熔点: N/A
• 闪点: N/A

CHK1-IN-2用途

CHK1-IN-2 是细胞周期检测点激酶 (CHK1) 的抑制剂,其 IC50 为 6 nM。

CHK1-IN-2名称

• 中文名: CHK1-IN-2
• 英文名: CHK1-IN-2

CHK1-IN-2生物活性

• 描述: CHK1-IN-2 是细胞周期检测点激酶 (CHK1) 的抑制剂,其 IC50 为 6 nM。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 检查点激酶(Chk)
  研究领域 >> 癌症
• 靶点实验:

  Chk1:6 nM (IC50)

• 体外研究: CHK1-IN-2是一种检查点激酶1(CHK1)抑制剂,IC50为6 nM,是一种潜在的癌症治疗药物,可用于增强DNA损伤剂的功效[1]。
• 参考文献:

  [1]. Yang B, et al. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors. J Med Chem. 2018 Feb 8;61(3):1061-1073.

CHK1-IN-2物理化学性质

• 分子式: C₂₀H₂₂N₄OS
• 分子量: 366.48
• InChIKey: LMQOZGSVTQQPFU-WBMJQRKESA-N
• SMILES: CC1NCCCC1Nc1ncc(C(N)=O)c2sc(-c3ccccc3)cc12
• 储存条件: 2-8°C，密封，干燥

CHK1-IN-2靶点实验

查看更多实验

实验名称：Volume of distribution at steady state in iv dosed rat plasma 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4037458

实验名称：Abrogation of topotecan-induced G2 phase arrest in human HCT116 cells xenografted in ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4037459

实验名称：Intrinsic clearance in Sprague-Dawley rat liver microsomes at 0.2 to 1 mM after 2 min... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4037441

实验名称：Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by patch c... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4037438

实验名称：Inhibition of CHK1 (unknown origin) 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4037437

实验名称：Inhibition of CHK1 in human SW620 cells assessed as potentiation of gemcitabine-induc... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4037448

实验名称：Inhibition of CHK1 in human H460 cells harboring dominant negative p53 construct asse... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4037449

实验名称：Inhibition of CHK1 in human MDA-MB-231 cells assessed as potentiation of gemcitabine-... 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL4037446

实验名称：Antiproliferative activity against human H460 cells harboring dominant negative p53 c... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL4037447

实验名称：Antiproliferative activity against human MDA-MB-231 cells 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4037444

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