苯-DC3

• 常用名: 苯-DC3
• 英文名: Phen-DC 3
• CAS号: 942936-75-6
• 分子量: 550.61
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₂₆N₆O₂
• 熔点: N/A
• 闪点: N/A

苯-DC3用途

Phen-DC3 是一个 G4 特异性配体,可以抑制解旋酶 FANCJ 和 DinG 且 IC50s 值分别为 65±6 和 50±10 nM。

苯-DC3名称

• 中文名: 苯-DC3
• 英文名: Phen-DC3

苯-DC3生物活性

• 描述: Phen-DC3 是一个 G4 特异性配体,可以抑制解旋酶 FANCJ 和 DinG 且 IC50s 值分别为 65±6 和 50±10 nM。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 其他
• 靶点实验:

  IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)[1].

• 参考文献:

  [1]. Bharti SK, et al. Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem. 2013 Sep 27; 288(39):28217-29.

苯-DC3物理化学性质

• 分子式: C₃₄H₂₆N₆O₂
• 分子量: 550.61

苯-DC3靶点实验

查看更多实验

实验名称：Binding affinity to human telomeric repeat F21T assessed as change in melting tempera... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5235449

实验名称：Inhibition of recombinant NCL (unknown origin)/EB virusG4-EBNA1 mRNA interaction at 1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4364536

实验名称：Binding affinity to double-stranded DNA FdxT (unknown origin) assessed as change in m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5235451

实验名称：Binding affinity to c-MYC promoter G4 sequences FmycT (unknown origin) assessed as ch... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5235450

实验名称：Decrease in telomerase processivity assessed as decrease in telomerase elongation in ... 来源：ChEMBL 靶标：Telomerase reverse transcriptase External Id：CHEMBL926073

实验名称：Inhibition of human telomerase elongation activity expressed in HEK293T cells in pres... 来源：ChEMBL 靶标：Telomerase reverse transcriptase External Id：CHEMBL939950

实验名称：Displacement of TO from EB virus g4-EBNA1 mRNA measured after 5 mins by FID assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4364529

实验名称：Binding affinity to F-myc22-T mRNA (unknown origin) assessed as increase in melting t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4364528

实验名称：Binding affinity to human F-25TAG-T mRNA assessed as increase in melting temperature ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4364527

实验名称：Helicase Assays from Article 10.1074/jbc.M113.496463: "Specialization among iron-sulf... 来源：BindingDB 靶标：N/A External Id：BindingDB_7729_1

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