Lck抑制剂2

更新时间：2025-08-25 20:08:18

Lck抑制剂2结构式	常用名	Lck抑制剂2	英文名	Lck inhibitor 2
	CAS号	944795-06-6	分子量	335.36000
	密度	N/A	沸点	N/A
	分子式	C₁₈H₁₇N₅O₂	熔点	N/A
	MSDS	N/A	闪点	N/A

Lck抑制剂2用途

Lck inhibitor 2是多靶点酪氨酸激酶抑制剂,对Lck,Btk,Lyn,Btk和Txk的IC50分别为13nM,9nM,3nM,26nM和2nM。

中文名	Lck抑制剂2
英文名	3-({4-[(5-Hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)benza mide
英文别名	更多

描述	Lck inhibitor 2是多靶点酪氨酸激酶抑制剂,对Lck,Btk,Lyn,Btk和Txk的IC50分别为13nM,9nM,3nM,26nM和2nM。
相关类别	信号通路 >> 蛋白酪氨酸激酶 >> SRC 研究领域 >> 炎症/免疫
参考文献	[1]. Bamborough, et al. Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery. Journal of Medicinal Chemistry (2008), 51(24), 7898-7914. [2]. Bamborough, Paul, et al. N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics. Bioorganic & Medicinal Chemistry Letters (2007), 17(15), 4363-4368. [3]. Awale, Mahendra, et al. Molecular docking guided 3D-QSAR CoMFA analysis of N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of leukocyte-specific protein tyrosine kinase. Journal of Molecular Modeling (2008), 14(10), 937-947.

描述

Lck inhibitor 2是多靶点酪氨酸激酶抑制剂,对Lck,Btk,Lyn,Btk和Txk的IC50分别为13nM,9nM,3nM,26nM和2nM。

相关类别

信号通路 >> 蛋白酪氨酸激酶 >> SRC

研究领域 >> 炎症/免疫

参考文献

[1]. Bamborough, et al. Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery. Journal of Medicinal Chemistry (2008), 51(24), 7898-7914.

[2]. Bamborough, Paul, et al. N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics. Bioorganic & Medicinal Chemistry Letters (2007), 17(15), 4363-4368.

[3]. Awale, Mahendra, et al. Molecular docking guided 3D-QSAR CoMFA analysis of N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of leukocyte-specific protein tyrosine kinase. Journal of Molecular Modeling (2008), 14(10), 937-947.

分子式	C₁₈H₁₇N₅O₂
分子量	335.36000
精确质量	335.13800
PSA	117.38000
LogP	3.45580
InChIKey	SFCBIFOAGRZJNX-UHFFFAOYSA-N
SMILES	Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(C(N)=O)c2)n1
储存条件	2-8℃

实验名称：Binding affinity to human ALK4 at 10 uM relative to control
来源：ChEMBL
靶标：Activin receptor type-1B
External Id：CHEMBL993460

实验名称：Binding affinity to human ALK2 at 10 uM relative to control
来源：ChEMBL
靶标：Activin receptor type-1
External Id：CHEMBL993459

实验名称：Binding affinity to human GCN2 at 10 uM relative to control
来源：ChEMBL
靶标：eIF-2-alpha kinase GCN2
External Id：CHEMBL993456

实验名称：Binding affinity to human GAK at 10 uM relative to control
来源：ChEMBL
靶标：Cyclin-G-associated kinase
External Id：CHEMBL993455

实验名称：Binding affinity to human ALK1 at 10 uM relative to control
来源：ChEMBL
靶标：Serine/threonine-protein kinase receptor R3
External Id：CHEMBL993458

实验名称：Binding affinity to human MYT1 at 10 uM relative to control
来源：ChEMBL
靶标：Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
External Id：CHEMBL993457

实验名称：Inhibition of murine Lck by TR-FRET assay
来源：ChEMBL
靶标：Proto-oncogene tyrosine-protein kinase LCK
External Id：CHEMBL923137

实验名称：Inhibition of Txk
来源：ChEMBL
靶标：Tyrosine-protein kinase TXK
External Id：CHEMBL923141

实验名称：Inhibition of Btk
来源：ChEMBL
靶标：Tyrosine-protein kinase BTK
External Id：CHEMBL923138

实验名称：Inhibition of Lyn
来源：ChEMBL
靶标：Tyrosine-protein kinase Lyn
External Id：CHEMBL923139

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