Ezutromid

• 常用名: Ezutromid
• 英文名: Ezutromid
• CAS号: 945531-77-1
• 分子量: 337.39200
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₅NO₃S
• 熔点: N/A
• 闪点: N/A

Ezutromid用途

Ezutromid是一个小分子utrophin的调制器

Ezutromid名称

• 中文名: Ezutromid
• 英文名: 5-ethylsulfonyl-2-naphthalen-2-yl-1,3-benzoxazole

Ezutromid生物活性

• 描述: Ezutromid是一个小分子utrophin的调制器
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Tinsley JM et al. Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse. PLoS One. 2011 May 6;6(5):e19189.

  [2]. Tinsley J et al. Safety, tolerability, and pharmacokinetics of SMT C1100, a 2-arylbenzoxazole utrophin modulator, following single- and multiple-dose administration to healthy male adult volunteers. J Clin Pharmacol. 2015 Jun;55(6):698-707.

  [3]. Guiraud S et al. Second-generation compound for the modulation of utrophin in the therapy of DMD. Hum Mol Genet. 2015 Aug 1;24(15):4212-24.

Ezutromid物理化学性质

• 分子式: C₁₉H₁₅NO₃S
• 分子量: 337.39200
• 精确质量: 337.07700
• PSA: 68.55000
• LogP: 5.52240
• InChIKey: KSGCNXAZROJSNW-UHFFFAOYSA-N
• SMILES: CCS(=O)(=O)c1ccc2oc(-c3ccc4ccccc4c3)nc2c1
• 储存条件: 2-8℃

Ezutromid靶点实验

查看更多实验

实验名称：Lipophilicity, logD of the compound at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378669

实验名称：Permeability at pH 7.4 by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378671

实验名称：Protein binding in mouse plasma assessed as bound fraction 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378672

实验名称：Protein binding in human plasma assessed as bound fraction 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378673

实验名称：Half life in mouse liver S9 fraction 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378674

实验名称：Induction of CYP2B enzymes in female minipig assessed as increase in PROD enzyme acti... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378661

实验名称：Induction of CYP1A1/2 enzymes in male minipig assessed as increase in EROD enzyme act... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378662

实验名称：Induction of CYP2B enzymes in male minipig assessed as increase in PROD enzyme activi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378663

实验名称：Induction of CYP3A enzymes in minipig assessed as increase in testosterone hydroxylas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378664

实验名称：Induction of CYP2E1 enzymes in minipig assessed as increase in 11-hydroxylase activit... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4378665

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Ezutromid英文别名

• UNII-645R07LF0D
• BMN 195
• SMT c1100
• Ezutromid