ML365

• 常用名: ML365
• 英文名: ML 365
• CAS号: 947914-18-3
• 分子量: 360.40600
• 密度: 1.253±0.06 g/cm3 (20 °C, 760 mmHg)
• 沸点: 429.9±40.0 °C (760 mmHg)
• 分子式: C₂₂H₂₀N₂O₃
• 熔点: N/A
• 闪点: N/A

ML365用途

ML365是一新型选择性TASK1(KCNK3)小分子抑制剂,IC50值为4nM(thallium influx fluorescent assay)。

ML365名称

• 中文名: ML365
• 英文名: Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]

ML365生物活性

• 描述: ML365是一新型选择性TASK1(KCNK3)小分子抑制剂,IC50值为4nM(thallium influx fluorescent assay)。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钾通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Zou B, et al. ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML365物理化学性质

• 密度: 1.253±0.06 g/cm3 (20 °C, 760 mmHg)
• 沸点: 429.9±40.0 °C (760 mmHg)
• 分子式: C₂₂H₂₀N₂O₃
• 分子量: 360.40600
• 精确质量: 360.14700
• PSA: 67.43000
• LogP: 4.65420
• InChIKey: UTAJHKSGYJSZBR-UHFFFAOYSA-N
• SMILES: COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1
• 储存条件: 2-8℃

ML365靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：SAR Analysis for the identification of selective inhibitors of the two-pore domain po... 来源：Johns Hopkins Ion Channel Center 靶标：potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] External Id：JHICC_K9_Inh_SAR_Q2_CRC_2

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

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ML365英文别名

• ML365