4-(2,4-Dichlorophenylamino)-7-methoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide

• 常用名: 4-(2,4-Dichlorophenylamino)-7-methoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide
• 英文名: 4-(2,4-Dichlorophenylamino)-7-methoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide
• CAS号: 953798-86-2
• 分子量: 460.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₃Cl₂N₅O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-(2,4-Dichlorophenylamino)-7-methoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide

物理化学性质

• 分子式: C₂₂H₂₃Cl₂N₅O₂
• 分子量: 460.4
• InChIKey: UWMKTPGQKQFRHE-UHFFFAOYSA-N
• SMILES: COc1cc2ncc(C(N)=O)c(Nc3ccc(Cl)cc3Cl)c2cc1N1CCN(C)CC1

靶点实验

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实验名称：Inhibition of CSF1R 来源：ChEMBL 靶标：Macrophage colony-stimulating factor 1 receptor External Id：CHEMBL1025517

实验名称：Aqueous solubility of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1025519

实验名称：Antiproliferative activity against mouse 3T3 cells expressing human CSF1R after 72 hr... 来源：ChEMBL 靶标：NIH3T3 External Id：CHEMBL1025518

实验名称：Half life in rat at 3 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1025524

实验名称：Bioavailability in rat at 3 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1025521

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301365

实验名称：Plasma protein binding assessed as percentage unbound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1025520

实验名称：Volume of distribution at steady state in rat at 3 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1025523

实验名称：Clearance in rat at 3 mg/kg, iv and 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1025522

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