4-(2,4-Dichlorophenylamino)-7-methoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide
Modify Date: 2025-09-15 12:12:46
4-(2,4-Dichlorophenylamino)-7-methoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide structure
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Common Name | 4-(2,4-Dichlorophenylamino)-7-methoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide | ||
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| CAS Number | 953798-86-2 | Molecular Weight | 460.4 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23Cl2N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
| Name | 4-(2,4-Dichlorophenylamino)-7-methoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxamide |
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| Molecular Formula | C22H23Cl2N5O2 |
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| Molecular Weight | 460.4 |
| InChIKey | UWMKTPGQKQFRHE-UHFFFAOYSA-N |
| SMILES | COc1cc2ncc(C(N)=O)c(Nc3ccc(Cl)cc3Cl)c2cc1N1CCN(C)CC1 |
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Name: Inhibition of CSF1R
Source: ChEMBL
Target: Macrophage colony-stimulating factor 1 receptor
External Id: CHEMBL1025517
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Name: Antiproliferative activity against mouse 3T3 cells expressing human CSF1R after 72 hr...
Source: ChEMBL
Target: NIH3T3
External Id: CHEMBL1025518
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Name: Half life in rat at 3 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1025524
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Name: Bioavailability in rat at 3 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1025521
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Name: ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301365
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Name: Plasma protein binding assessed as percentage unbound
Source: ChEMBL
Target: N/A
External Id: CHEMBL1025520
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Name: Volume of distribution at steady state in rat at 3 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1025523
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Name: Clearance in rat at 3 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1025522
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