2-(2-氯苯基)-4-甲基-5-(吡啶-2-基甲基)-1H-吡唑并[4,3-c]吡啶-3,6(2H,5H)-二酮

• 常用名: 2-(2-氯苯基)-4-甲基-5-(吡啶-2-基甲基)-1H-吡唑并[4,3-c]吡啶-3,6(2H,5H)-二酮
• 英文名: GKT136901
• CAS号: 955272-06-7
• 分子量: 366.80100
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₅ClN₄O₂
• 熔点: N/A
• 闪点: N/A

用途

GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 also is a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity.

名称

• 中文名: 2-(2-氯苯基)-4-甲基-5-(吡啶-2-基甲基)-1H-吡唑并[4,3-c]吡啶-3,6(2H,5H)-二酮
• 英文名: 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione

物理化学性质

• 分子式: C₁₉H₁₅ClN₄O₂
• 分子量: 366.80100
• 精确质量: 366.08800
• PSA: 72.68000
• LogP: 2.88560
• InChIKey: DNKYHHFCPXKFIY-UHFFFAOYSA-N
• SMILES: Cc1c2c(=O)n(-c3ccccc3Cl)[nH]c2cc(=O)n1Cc1ccccn1
• 储存条件: 2-8°C，干燥密封

安全信息

• 海关编码: 2933990090

海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靶点实验

查看更多实验

实验名称：Tmax in Sprague-Dawley rat at 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1286985

实验名称：AUC (infinity) in Sprague-Dawley rat at 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1286987

实验名称：Half life in Sprague-Dawley rat at 5 mg/kg, iv 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1286991

实验名称：Clearance in Sprague-Dawley rat at 5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1286992

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：Intrinsic clearance in human liver microsomes assessed as per mg of protein at 0.5 uM 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1286980

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：AUC (infinity) in Sprague-Dawley rat at 10 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1286982

实验名称：Oral bioavailability in Sprague-Dawley rat at 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1286983

实验名称：Inhibition of MAO-B at 10 uM 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B External Id：CHEMBL1287073

共43条，当前第1页，共5页

1

2

3

4

5

英文别名

• 2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6-dione