TCS HDAC6 20b

• 常用名: TCS HDAC6 20b
• 英文名: TCS HDAC6 20b
• CAS号: 956154-63-5
• 分子量: 480.704
• 密度: 1.1±0.1 g/cm3
• 沸点: 631.3±55.0 °C at 760 mmHg
• 分子式: C₂₆H₄₄N₂O₄S
• 熔点: N/A
• 闪点: 335.6±31.5 °C

TCS HDAC6 20b用途

TCS HDAC6 20b是一种HDAC6选择性抑制剂。TCS HDAC6 20b阻断雌激素受体α阳性乳腺癌MCF-7细胞的生长【1】。

TCS HDAC6 20b名称

• 英文名: S-[(6S)-7-(Adamantan-1-ylamino)-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-7-oxoheptyl] 2-methylpropanethioate

TCS HDAC6 20b生物活性

• 描述: TCS HDAC6 20b是一种HDAC6选择性抑制剂。TCS HDAC6 20b阻断雌激素受体α阳性乳腺癌MCF-7细胞的生长【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> 表观遗传学 >> HDAC
• 参考文献:

  [1]. Yukihiro Itoh, et al. Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J Med Chem. 2007 Nov 1;50(22):5425-38.

TCS HDAC6 20b物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 631.3±55.0 °C at 760 mmHg
• 分子式: C₂₆H₄₄N₂O₄S
• 分子量: 480.704
• 闪点: 335.6±31.5 °C
• 精确质量: 480.302185
• LogP: 5.66
• InChIKey: DQZMLPMCOMRJOR-MOVGKWKRSA-N
• SMILES: CC(C)C(=O)SCCCCCC(NC(=O)OC(C)(C)C)C(=O)NC12CC3CC(CC(C3)C1)C2
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.537
• 储存条件: -20°C，密闭，干燥

TCS HDAC6 20b靶点实验

查看更多实验

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Growth inhibition of human HCT116 cells at 0.3 uM after 72 hrs 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL898814

实验名称：Growth inhibition of 17-beta-estradiol-induced ERalpha+ MCF7 cells at 5 uM after 72 h... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL898815

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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TCS HDAC6 20b英文别名

• Propanethioic acid, 2-methyl-, S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester
• S-[(6S)-7-(Adamantan-1-ylamino)-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-7-oxoheptyl] 2-methylpropanethioate
• S-[(6S)-6-[(tert-butoxycarbonyl)amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] 2-methylpropanethioate
• TCS HDAC6 20b