A-836339

• 常用名: A-836339
• 英文名: A-836339
• CAS号: 959746-77-1
• 分子量: 310.455
• 密度: 1.1±0.1 g/cm3
• 沸点: 388.4±44.0 °C at 760 mmHg
• 分子式: C₁₆H₂₆N₂O₂S
• 熔点: N/A
• 闪点: 188.7±28.4 °C

A-836339用途

A-836339是CB2受体选择性激动剂，对CB1受体作用基本无。

A-836339名称

• 中文名: A-836339
• 英文名: N-[3-(2-methoxyethyl)-4,5-dimethyl-1,3-thiazol-2-ylidene]-2,2,3,3-tetramethylcyclopropane-1-carboxamide

A-836339生物活性

• 描述: A-836339是CB2受体选择性激动剂,对CB1受体作用基本无。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Yao BB, et al. Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pa

  [2]. McGaraughty S, et al. A CB(2) receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: contributions of spinal and peripheral CB(2) receptors. Neuroscience. 2009 Feb 18;158(4):1652-61.

  [3]. Hsieh GC, et al. Central and peripheral sites of action for CB? receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats. Br J Pharmacol. 2011 Jan;162(2):428-40.

A-836339物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 388.4±44.0 °C at 760 mmHg
• 分子式: C₁₆H₂₆N₂O₂S
• 分子量: 310.455
• 闪点: 188.7±28.4 °C
• 精确质量: 310.171509
• PSA: 71.83000
• LogP: 3.88
• InChIKey: JKGIMVBQKSRTGX-UHFFFAOYSA-N
• SMILES: COCCn1c(C)c(C)sc1=NC(=O)C1C(C)(C)C1(C)C
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.561
• 储存条件: 2-8℃

A-836339英文别名

• N-[(2Z)-3-(2-Methoxyethyl)-4,5-dimethyl-1,3-thiazol-2(3H)-ylidene]-2,2,3,3-tetramethylcyclopropanecarboxamide
• a-836,339
• unii-z6y1j258eg
• A-836339