Deoxynyboquinone

更新时间：2025-08-22 12:28:39

Deoxynyboquinone结构式	常用名	Deoxynyboquinone	英文名	deoxynyboquinone
	CAS号	96748-86-6	分子量	284.267
	密度	1.5±0.1 g/cm3	沸点	591.2±50.0 °C at 760 mmHg
	分子式	C₁₅H₁₂N₂O₄	熔点	N/A
	MSDS	N/A	闪点	311.4±30.1 °C

Deoxynyboquinone用途

脱氧苯醌(NSC 165572；DNQ)是一种有效的癌细胞死亡诱导剂,可诱导培养物中癌细胞死亡,IC50为16-210 nM,是NAD(P)H：醌氧化还原酶(NQO1)的底物；它的致死性依赖于NQO1依赖的无效氧化还原循环,消耗氧气并产生广泛的活性氧(ROS)。

英文名	deoxynyboquinone
英文别名	更多

描述	脱氧苯醌(NSC 165572；DNQ)是一种有效的癌细胞死亡诱导剂,可诱导培养物中癌细胞死亡,IC50为16-210 nM,是NAD(P)H：醌氧化还原酶(NQO1)的底物；它的致死性依赖于NQO1依赖的无效氧化还原循环,消耗氧气并产生广泛的活性氧(ROS)。
参考文献	References 1. Bair JS, et al. J Am Chem Soc. 2010 Apr 21;132(15):5469-78. 2. Huang X, et al. Cancer Res. 2012 Jun 15;72(12):3038-47. 3. Lee HY, et al. ACS Chem Biol. 2017 May 19;12(5):1416-1424. View Related Products by Target Other Targets

密度	1.5±0.1 g/cm3
沸点	591.2±50.0 °C at 760 mmHg
分子式	C₁₅H₁₂N₂O₄
分子量	284.267
闪点	311.4±30.1 °C
精确质量	284.079712
LogP	-0.41
InChIKey	KJYPAIRTXRKKHG-UHFFFAOYSA-N
SMILES	Cc1cc(=O)[nH]c2c1C(=O)c1c(C)cc(=O)n(C)c1C2=O
蒸汽压	0.0±1.7 mmHg at 25°C
折射率	1.659

实验名称：Antibacterial activity against Escherichia coli ATCC 12435 after 16 to 48 hrs
来源：ChEMBL
靶标：Escherichia coli
External Id：CHEMBL4417494

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来源：ChEMBL
靶标：Salmonella enterica
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来源：ChEMBL
靶标：Saccharomyces cerevisiae
External Id：CHEMBL4417496

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来源：ChEMBL
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来源：ChEMBL
靶标：PC-3
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实验名称：Antibacterial activity against Enterococcus faecalis ATCC 29212
来源：ChEMBL
靶标：Enterococcus faecalis
External Id：CHEMBL4270959

实验名称：Antibacterial activity against Bacillus thuringiensis SCSIO BT01
来源：ChEMBL
靶标：Bacillus thuringiensis
External Id：CHEMBL4270930

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来源：ChEMBL
靶标：Eukaryotic translation initiation factor 4E-binding protein 1
External Id：CHEMBL4417501

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 6538 after 16 to 48 hrs
来源：ChEMBL
靶标：Staphylococcus aureus
External Id：CHEMBL4417490

实验名称：Antibacterial activity against Micrococcus luteus ATCC 15307 after 16 to 48 hrs
来源：ChEMBL
靶标：Micrococcus luteus
External Id：CHEMBL4417491

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deoxynyboquinone