Synlett

Direct Microwave Synthesis of N, N′-Diacylhydrazines and Boc-Protected Hydrazides by in situ Carbonylations under Air

MA Herrero, J Wannberg, M Larhed

Index: Herrero, Maria Antonia; Wannberg, Johan; Larhed, Mats Synlett, 2004 , # 13 p. 2335 - 2338

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Citation Number: 17

Abstract

Abstract Palladium-catalyzed hydrazidocarbonylations of aryl iodides and bromides were performed by controlled microwave irradiation, employing Mo (CO) 6 as a convenient CO source. A fluorous phosphine ligand was succesfully used to recycle the catalytic system. Finally, dehydration of a diacylhydrazine to the corresponding 1, 3, 4-oxadiazole was achieved with POCl 3 in a one-pot procedure.