Steroids

Microbial transformation of androst-4-ene-3, 17-dione by Beauveria bassiana

Z Xiong, Q Wei, H Chen, S Chen, W Xu, G Qiu, S Liang…

Index: Xiong, Zhigang; Wei, Qi; Chen, Hanmei; Chen, Shouwen; Xu, Wenjin; Qiu, Guofu; Liang, Shucai; Hu, Xianming Steroids, 2006 , vol. 71, # 11-12 p. 979 - 983

Full Text: HTML

Citation Number: 34

Abstract

The microbial transformation of androst-4-ene-3, 17-dione (I) by the fungus Beauveria bassiana CCTCC AF206001 has been investigated using pH 6.0 and 7.0 media. Two hydroxylated metabolites were obtained with the pH 6.0 medium. The major product was 11α-hydroxyandrost-4-ene-3, 17-dione (II) whereas the minor product was 6β, 11α- dihydroxyandrost-4-ene-3, 17-dione (III). On the other hand, four hydroxylated and/or ...