Tetrahedron

Thorpe–Ingold effect in the reaction of vicinal amino primary alcohol hydrogen sulfates and carbon disulfide

N Chen, Z Huang, C Zhou, J Xu

Index: Chen, Ning; Huang, Zhongyan; Zhou, Chan; Xu, Jiaxi Tetrahedron, 2011 , vol. 67, # 41 p. 7971 - 7976

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Citation Number: 6

Abstract

The Thorpe–Ingold effect is a key factor that affects the ring-closure rates and efficiency, as well as the structure of products in some ring-closure reactions. The reaction of vicinal amino primary alcohol hydrogen sulfates and carbon disulfide in the presence of potassium hydroxide produces the desired 4, 4-disubstituted thiazolidine-2-thiones, and their isomers 5, 5-disubstituted derivatives companying with their oxygen analogues 4, 4-disubstituted ...