2-Amino-2-methyl-1-propanol

Modify Date: 2026-07-01 14:40:34

2-Amino-2-methyl-1-propanol Structure
2-Amino-2-methyl-1-propanol structure
 Common Name 2-Amino-2-methyl-1-propanol
CAS Number 124-68-5 Molecular Weight 89.14
Density 0.9±0.1 g/cm3 Boiling Point 167.2±13.0 °C at 760 mmHg
Molecular Formula C4H11NO Melting Point 24-28 °C(lit.)
MSDS Chinese USA Flash Point 67.2±0.0 °C
Symbol GHS05
GHS05		 Signal Word Danger

 Use of 2-Amino-2-methyl-1-propanol


2-Amino-2-methyl-1-propanol (AMP) is a neutralizer, buffer and surfactant[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2-Amino-2-methyl-1-propanol
Synonym More Synonyms

 2-Amino-2-methyl-1-propanol Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 2-Amino-2-methyl-1-propanol (AMP) is a neutralizer, buffer and surfactant[1].
Related Catalog
References

[1]. Hong NS, et al. Rapid and accurate determination of deoxyribonucleoside monophosphates from DNA using micellar electrokinetic chromatography with a cationic surfactant additive. Anal Bioanal Chem. 2011 Jun;400(7):2131-40.  

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 0.9±0.1 g/cm3
Boiling Point 167.2±13.0 °C at 760 mmHg
Melting Point 24-28 °C(lit.)
Molecular Formula C4H11NO
Molecular Weight 89.14
Flash Point 67.2±0.0 °C
Exact Mass 89.084061
PSA 46.25000
LogP -0.61
Vapour density 3 (vs air)
Vapour Pressure 0.6±0.7 mmHg at 25°C
Index of Refraction 1.447
InChIKey CBTVGIZVANVGBH-UHFFFAOYSA-N
SMILES CC(C)(N)CO
Storage condition Store at RT.
Stability Stable. Combustible. Incompatible with strong oxidizing agents. May present an explosion hazard if heated.
Water Solubility miscible

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UA5950000
CHEMICAL NAME :
1-Propanol, 2-amino-2-methyl-
CAS REGISTRY NUMBER :
124-68-5
BEILSTEIN REFERENCE NO. :
0505979
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C4-H11-N-O
MOLECULAR WEIGHT :
89.16
WISWESSER LINE NOTATION :
ZX1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 22,315,1940 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
44800 mg/kg/8W-C
TOXIC EFFECTS :
Liver - other changes Skin and Appendages - hair Related to Chronic Data - death
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
230 ug/m3/4H/13W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight Lungs, Thorax, or Respiration - changes in lung weight Related to Chronic Data - changes in uterine weight
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
11340 mg/kg/28D-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
6 mg/m3/89D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
100 mg/m3/4H/13W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(2),203,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M5222 No. of Facilities: 2958 (estimated) No. of Industries: 28 No. of Occupations: 44 No. of Employees: 24640 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M5222 No. of Facilities: 16965 (estimated) No. of Industries: 136 No. of Occupations: 94 No. of Employees: 219300 (estimated) No. of Female Employees: 54846 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H315-H318-H412
Precautionary Statements P273-P280-P305 + P351 + P338 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/38;R52/53
Safety Phrases S61
RIDADR 2735
WGK Germany 1
RTECS UA5950000
Packaging Group III
HS Code 2922199090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles43

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Effect of selective heparin desulfation on preservation of bone morphogenetic protein-2 bioactivity after thermal stress.

Bioconjug. Chem. 26(2) , 286-93, (2015)

Bone morphogenetic protein-2 (BMP-2) plays an important role in bone and cartilage formation and is of interest in regenerative medicine. Heparin can interact electrostatically with BMP-2 and thus has...

Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation.

Bone 79 , 43-51, (2015)

Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression o...

Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.

Toxicol. Mech. Methods 18 , 217-27, (2008)

ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...

 2-Amino-2-methyl-1-propanolBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: qHTS assay to identify small molecule antagonists of the peroxisome proliferator-acti...
Source: 824
Target: N/A
External Id: PPARGV841
Name: qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway...
Source: 824
Target: N/A
External Id: TGF788
Name: qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling path...
Source: 824
Target: N/A
External Id: TGF602
Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell fr...
Source: 824
Target: N/A
External Id: SPEC167MG
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: qHTS assay to identify small molecule agonists of the peroxisome proliferator-activat...
Source: 824
Target: N/A
External Id: PPARDV813
Name: qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free...
Source: 824
Target: N/A
External Id: SPEC167MR
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells
Source: 824
Target: N/A
External Id: SPEC167CG
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2-Amino-2-methyl-1-propanol
2,2-Dimethyl-ethanolamine
EINECS 204-709-8
2-Amino-2-methyl-propan-1-ol
2-Amino-2-Methylpropan-1-Ol
MFCD00008051
Aminomethyl propanol
1,1-Dimethyl-2-hydroxyethylamine

 2-Amino-2-methyl-1-propanol | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What English synonyms does 2-Amino-2-methyl-1-propanol have?
A: English synonyms of 2-Amino-2-methyl-1-propanol: 2-Amino-2-methyl-1-propanol, 2,2-Dimethyl-ethanolamine, EINECS 204-709-8, 2-Amino-2-methyl-propan-1-ol, 2-Amino-2-Methylpropan-1-Ol, MFCD00008051, Aminomethyl propanol, 1,1-Dimethyl-2-hydroxyethylamine.
Q: What is the English name of 2-Amino-2-methyl-1-propanol?
A: The English name of 2-Amino-2-methyl-1-propanol is 2-Amino-2-methyl-1-propanol.
Q: What is the CAS number of 2-Amino-2-methyl-1-propanol?
A: CAS number of 2-Amino-2-methyl-1-propanol is 124-68-5.
Q: What is the boiling point of 2-Amino-2-methyl-1-propanol?
A: Boiling point of 2-Amino-2-methyl-1-propanol is 167.2±13.0 °C at 760 mmHg.
Q: What is the safety information for 2-Amino-2-methyl-1-propanol?
A: Safety information for 2-Amino-2-methyl-1-propanol: S61.
Q: How is the water solubility of 2-Amino-2-methyl-1-propanol?
A: Water solubility of 2-Amino-2-methyl-1-propanol: miscible.
Q: What is the InChIKey of 2-Amino-2-methyl-1-propanol?
A: InChIKey of 2-Amino-2-methyl-1-propanol is CBTVGIZVANVGBH-UHFFFAOYSA-N.
Q: What is the polar surface area (PSA) of 2-Amino-2-methyl-1-propanol?
A: Polar surface area (PSA) of 2-Amino-2-methyl-1-propanol is 46.25000.
Q: What are the upstream materials of 2-Amino-2-methyl-1-propanol?
A: Related upstream materials(CAS) of 2-Amino-2-methyl-1-propanol: 76-39-1;13257-67-5;1113-49-1;15028-41-8;62-57-7;82922-13-2;87730-42-5;102520-97-8;64-17-5.
Q: What is the molecular weight of 2-Amino-2-methyl-1-propanol?
A: Molecular weight of 2-Amino-2-methyl-1-propanol is 89.14.

 2-Amino-2-methyl-1-propanolfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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Chemsrc provides 2-Amino-2-methyl-1-propanol(CAS#:124-68-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 2-Amino-2-methyl-1-propanol are included as well.>> amp version: 2-Amino-2-methyl-1-propanol

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