The Journal of Organic Chemistry

Synthesis of tri-and tetrapeptide S: the extended C-terminus of bleomycin A2

DL Boger, RF Menezes

Index: Boger, Dale L.; Menezes, Royce F. Journal of Organic Chemistry, 1992 , vol. 57, # 16 p. 4331 - 4333

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Citation Number: 22

Abstract

Synthesis of Tri- and Tetrapeptide S: The Extended C-Terminus of Bleomycin A2 ... Dale L. Boger* and Royce F. Menezes Department of Chemistry, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, California 92037 Received February 24, 1992 ... Summary: Concise diastereocontrolled syntheses of tri- and tetrapeptide S, key subunits of the antitumor anti- biotic bleomycin A2, are detailed. Bleomycin A2 (I), the major naturally- ...