Synthesis and anti-inflammatory activity of 2, 3-diaryl-4 (3H)-quinazolinones

MR Yadav, ST Shirude, A Parmar, R Balaraman…

Index: Yadav; Shirude; Parmar; Balaraman; Giridhar Chemistry of Heterocyclic Compounds, 2006 , vol. 42, # 8 p. 1038 - 1045

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Citation Number: 25

Abstract

Abstract 2, 3-Diaryl-4 (3H)-quinazolinones containing various substituents on diaryl rings have been synthesized and evaluated for their cyclooxygenase-2 inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay and anti-inflammatory activity by the carrageenan-induced rat paw edema assay. 2-(4-Nitrophenyl)-3-(4-tolyl)-4 (3H)- quinazolinone showed a maximum COX-2 inhibition of 27.72% at 22 µM concentration in ...

~21%

~10%

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