One??Pot Synthesis of Mono??and Disubstituted (3 H)??Quinazolin??4??ones in Dry Media Under Microwave Irradiation

M Dabiri, P Salehi, AA Mohammadi…

Index: Dabiri, Minoo; Salehi, Peyman; Mohammadi, Ali A.; Baghbanzadeh, Mostafa Synthetic Communications, 2005 , vol. 35, # 2 p. 279 - 287

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Citation Number: 43

Abstract

Abstract AlCl3/ZnCl2 mixture supported on silica gel is an efficient medium for one??pot synthesis of (3 H)??quinazolin??4??ones in the absence of solvent under microwave irradiation or classical heating. The reaction of orthoesters with 2??aminobenzamides ends up with the formation of monosubstituted (3 H)??quinazolin??4??ones. One??pot synthesis of disubstituted (3 H)??quinazolin??4??ones is also achieved by the reaction of isatoic anhydride with primary ...