Journal of the American Chemical Society

A versatile catalyst for Heck reactions of aryl chlorides and aryl bromides under mild conditions

AF Littke, GC Fu

Index: Dai; Fu Journal of the American Chemical Society, 2001 , vol. 123, # 12 p. 2719 - 2724

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Citation Number: 621

Abstract

In the presence of Cy2NMe, Pd/P (t-Bu) 3 serves as an exceptionally mild and versatile catalyst for Heck reactions of aryl chlorides and bromides. A sterically and electronically diverse array of aryl bromides, as well as activated aryl chlorides, couple with a range of mono-and disubstituted olefins at room temperature, furnishing the arylated product with high E/Z stereoselection. The corresponding reactions of a broad spectrum of electron- ...