Arylethanolamines derived from salicylamide with. alpha.-and. beta.-adrenoceptor blocking activities. Preparation of labetalol, its enantiomers and related …

JE Clifton, I Collins, P Hallett, D Hartley…

Index: Clifton; Collins; Hallett; Hartley; Lunts; Wicks Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 670 - 679

Full Text: HTML

Citation Number: 48

Abstract

24 (1,4-Benzodioxan-2-yl)methyl]imidazole Hydrochloride (10). To a mixture of 35 g (200 mmol) of 4,16a,b 14 g of ethanol, and 100 mL of diethyl ether was added 12 g of HC1 gas. The flask containing the mixture was tightly stoppered and left at 5 "C for 4 days, at which time the solid imidate hydrochloride 7 was isolated by filtration. After the solid was washed with diethyl ether, there was obtained 35 g (-68%), which was used without further purification. A ...