5-(Bromoacetyl)salicylamide

Modify Date: 2024-01-02 10:10:18

5-(Bromoacetyl)salicylamide structure	Common Name	5-(Bromoacetyl)salicylamide
	CAS Number	73866-23-6	Molecular Weight	258.069
	Density	1.7±0.1 g/cm3	Boiling Point	420.2±40.0 °C at 760 mmHg
	Molecular Formula	C₉H₈BrNO₃	Melting Point	200-210°C
	MSDS	USA	Flash Point	207.9±27.3 °C

Name	5-Bromoacetyl Salicylamide
Synonym	More Synonyms

Density	1.7±0.1 g/cm3
Boiling Point	420.2±40.0 °C at 760 mmHg
Melting Point	200-210°C
Molecular Formula	C₉H₈BrNO₃
Molecular Weight	258.069
Flash Point	207.9±27.3 °C
Exact Mass	256.968750
PSA	80.39000
LogP	2.15
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.645

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: 5-Bromoacetyl salicylamide
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

H302:Harmful if swallowed
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
Avoid breathing dust/fume/gas/mist/vapours/spray
P261:
P280:Wear protective gloves/protective clothing/eye protection/face protection
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340:IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405:Store locked up

Section3. Composition/information on ingredients.
Ingredient name:5-Bromoacetyl salicylamide
CAS number:73866-23-6

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels, refrigerated.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C9H8BrNO3
Molecular weight:258.1

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV2365900

CHEMICAL NAME :: Benzamide, 5-(bromoacetyl)-2-hydroxy-

CAS REGISTRY NUMBER :: 73866-23-6

BEILSTEIN REFERENCE NO. :: 3286223

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H8-Br-N-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,59,1990

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37/39
RTECS	CV2365900
HS Code	2924299090

5-Acetyl-2-hydr...

CAS#:40187-51-7

~67%

5-(Bromoacetyl)...

CAS#:73866-23-6

Literature: Narayana; Vijaya Raj; Ashalatha; Kumari, N. Suchetha; Sarojini European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 867 - 872

Precursor 1
CAS#:40187-51-7 5-Acetyl-2-hydr...
DownStream 1
CAS#:30566-92-8 5-(N,N-Dibenzyl...

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%