Journal of Chemical Research

Efficient chemoselective addition of Grignard reagents to carbonyl compounds in 2-methyltetrahydrofuran

W Zhong, Y Wu, X Zhang

Index: Zhong, Weihui; Wu, Yaotiao; Zhang, Xingxian Journal of Chemical Research, 2009 , # 6 p. 370 - 373

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Citation Number: 2

Abstract

Compared with tetrahydrofuran (THF) as a solvent for the addition reactions between Grignard reagents and carbonyl compounds 2-methyltetrahydrofuran affords the corresponding adducts in higher yields with higher chemoselectivities. Moreover, 2- methyltetrahydrofuran can be readily recycled and reused, which lowers the cost of the process and makes the reaction greener.